{"_buckets": {"deposit": "32bdfe05-cc1f-4dce-b2a9-55a1c1f14f4b"}, "_deposit": {"id": "16619", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16619"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016619", "sets": ["456", "1106"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Onset and Pathogenesis in Rheumatoid Arthritis and its Treatment"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "379", "bibliographicPageStart": "371", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To study joint destruction and osteoporosis in patients with rheumatoid arthritis (RA), we investigated bone loss using histomorphometric analysis. We also examined the property of colony forming unit-fibroblastic (CFU-F) isolated from tibial bone marrow in rats with collagen-induced arthritis (CIA) and iliac bone marrow in human. Our findings showed decreases of parameters of bone formation and of the number of alkaline phosphatase-positive CFU-F during onset of arthritis. We speculated that reduced bone formation was the predominant mechanism of bone loss in the pathogenesis of RA. We also demonstrated that the lymphocytes in the joints of CIA comprised resident T cells that are extrathymically generated in situ. In vivo treatment with various monoclonal antibody, these γδT cells and CD 8 _\u003cαα\u003e^+ cells were associated with suppression of the disease, especially after its onset. On the other hand, in patients with RA, CD57^+T cells levels were elevated, especially high in joints and its adjacent bone marrow. CD57^+T cells contained higher proportions of CD ^4-^8- cells and γδT cells than CD57^-T cells. We suggested that CD57^+T cells with NK cell marker probably were a counterpart of extrathymic T cells in human and had unique immuno-suppressive functions. In rats with CIA, great increase in number of granulocytes were also observed before the onset of arthritis. From these results, we are performing the evaluation of these treatment which makes it possible to decrease the granulocytes or to increase the CD57^+T cells using previous analysis system of bone formation.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "105615", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hanyu, Tadamasa"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "羽生, 忠正"}], "nameIdentifiers": [{"nameIdentifier": "105614", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(7)_371-379.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "112(7)_371-379.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16619/files/112(7)_371-379.pdf"}, "version_id": "dfd84f3a-c98e-4f3a-82ab-58a6b6a55219"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "rheumatoid arthritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histomorphometry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bone formation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "extrathymic T cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "granulocytes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "慢性関節リウマチ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "組織形態計測", "subitem_subject_scheme": "Other"}, {"subitem_subject": "骨形成", "subitem_subject_scheme": "Other"}, {"subitem_subject": "胸腺外分化T細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "顆粒球", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "慢性関節リウマチ(RA)の発症および病態解明とその治療", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "慢性関節リウマチ(RA)の発症および病態解明とその治療"}, {"subitem_title": "慢性関節リウマチ(RA)の発症および病態解明とその治療", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1106"], "permalink_uri": "http://hdl.handle.net/10191/45971", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-02-02"}, "publish_date": "2017-02-02", "publish_status": "0", "recid": "16619", "relation": {}, "relation_version_is_last": true, "title": ["慢性関節リウマチ(RA)の発症および病態解明とその治療"], "weko_shared_id": null}