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慢性関節リウマチ(RA)の発症および病態解明とその治療
http://hdl.handle.net/10191/45971
http://hdl.handle.net/10191/459712c9f9b6e-53e7-4eec-bbe9-5f5aad4b47a2
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-02-02 | |||||
タイトル | ||||||
タイトル | 慢性関節リウマチ(RA)の発症および病態解明とその治療 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 慢性関節リウマチ(RA)の発症および病態解明とその治療 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rheumatoid arthritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histomorphometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone formation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | extrathymic T cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | granulocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 慢性関節リウマチ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 組織形態計測 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨形成 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胸腺外分化T細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 顆粒球 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Onset and Pathogenesis in Rheumatoid Arthritis and its Treatment | |||||
著者 |
羽生, 忠正
× 羽生, 忠正 |
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著者別名 | ||||||
識別子 | 105615 | |||||
識別子Scheme | WEKO | |||||
姓名 | Hanyu, Tadamasa | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To study joint destruction and osteoporosis in patients with rheumatoid arthritis (RA), we investigated bone loss using histomorphometric analysis. We also examined the property of colony forming unit-fibroblastic (CFU-F) isolated from tibial bone marrow in rats with collagen-induced arthritis (CIA) and iliac bone marrow in human. Our findings showed decreases of parameters of bone formation and of the number of alkaline phosphatase-positive CFU-F during onset of arthritis. We speculated that reduced bone formation was the predominant mechanism of bone loss in the pathogenesis of RA. We also demonstrated that the lymphocytes in the joints of CIA comprised resident T cells that are extrathymically generated in situ. In vivo treatment with various monoclonal antibody, these γδT cells and CD 8 _<αα>^+ cells were associated with suppression of the disease, especially after its onset. On the other hand, in patients with RA, CD57^+T cells levels were elevated, especially high in joints and its adjacent bone marrow. CD57^+T cells contained higher proportions of CD ^4-^8- cells and γδT cells than CD57^-T cells. We suggested that CD57^+T cells with NK cell marker probably were a counterpart of extrathymic T cells in human and had unique immuno-suppressive functions. In rats with CIA, great increase in number of granulocytes were also observed before the onset of arthritis. From these results, we are performing the evaluation of these treatment which makes it possible to decrease the granulocytes or to increase the CD57^+T cells using previous analysis system of bone formation. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 112, 号 7, p. 371-379, 発行日 1998-07 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |