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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第7号

慢性関節リウマチ(RA)の発症および病態解明とその治療

http://hdl.handle.net/10191/45971
http://hdl.handle.net/10191/45971
2c9f9b6e-53e7-4eec-bbe9-5f5aad4b47a2
名前 / ファイル ライセンス アクション
112(7)_371-379.pdf 112(7)_371-379.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-02
タイトル
タイトル 慢性関節リウマチ(RA)の発症および病態解明とその治療
タイトル
言語 en
タイトル 慢性関節リウマチ(RA)の発症および病態解明とその治療
言語
言語 jpn
キーワード
主題Scheme Other
主題 rheumatoid arthritis
キーワード
主題Scheme Other
主題 histomorphometry
キーワード
主題Scheme Other
主題 bone formation
キーワード
主題Scheme Other
主題 extrathymic T cells
キーワード
主題Scheme Other
主題 granulocytes
キーワード
主題Scheme Other
主題 慢性関節リウマチ
キーワード
主題Scheme Other
主題 組織形態計測
キーワード
主題Scheme Other
主題 骨形成
キーワード
主題Scheme Other
主題 胸腺外分化T細胞
キーワード
主題Scheme Other
主題 顆粒球
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Onset and Pathogenesis in Rheumatoid Arthritis and its Treatment
著者 羽生, 忠正

× 羽生, 忠正

WEKO 105614

羽生, 忠正

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著者別名
識別子 105615
識別子Scheme WEKO
姓名 Hanyu, Tadamasa
抄録
内容記述タイプ Abstract
内容記述 To study joint destruction and osteoporosis in patients with rheumatoid arthritis (RA), we investigated bone loss using histomorphometric analysis. We also examined the property of colony forming unit-fibroblastic (CFU-F) isolated from tibial bone marrow in rats with collagen-induced arthritis (CIA) and iliac bone marrow in human. Our findings showed decreases of parameters of bone formation and of the number of alkaline phosphatase-positive CFU-F during onset of arthritis. We speculated that reduced bone formation was the predominant mechanism of bone loss in the pathogenesis of RA. We also demonstrated that the lymphocytes in the joints of CIA comprised resident T cells that are extrathymically generated in situ. In vivo treatment with various monoclonal antibody, these γδT cells and CD 8 _<αα>^+ cells were associated with suppression of the disease, especially after its onset. On the other hand, in patients with RA, CD57^+T cells levels were elevated, especially high in joints and its adjacent bone marrow. CD57^+T cells contained higher proportions of CD ^4-^8- cells and γδT cells than CD57^-T cells. We suggested that CD57^+T cells with NK cell marker probably were a counterpart of extrathymic T cells in human and had unique immuno-suppressive functions. In rats with CIA, great increase in number of granulocytes were also observed before the onset of arthritis. From these results, we are performing the evaluation of these treatment which makes it possible to decrease the granulocytes or to increase the CD57^+T cells using previous analysis system of bone formation.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 7, p. 371-379, 発行日 1998-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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