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An OLETF Allele of Hyperglycemic QTL Nidd3/of Is Dominant
http://hdl.handle.net/10191/30607
http://hdl.handle.net/10191/30607b091fa87-2329-453c-96ae-16f007cd7356
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
57_2_135-138.pdf (1.0 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-12-01 | |||||
| タイトル | ||||||
| タイトル | An OLETF Allele of Hyperglycemic QTL Nidd3/of Is Dominant | |||||
| タイトル | ||||||
| タイトル | An OLETF Allele of Hyperglycemic QTL Nidd3/of Is Dominant | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | congenic | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dominant | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QTL | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Kose, Hiroyuki
× Kose, Hiroyuki× Yamada, Takahisa× Matsumoto, Kozo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344 genetic background. A prominent finding was that the F1 progeny between the congenic and the F344 stain, whose genotype is heterozygote at the Nidd3/of locus, showed mild hyperglycemia equal to the parental congenic rat, suggesting that the OLETF allele is dominant. To our knowledge, this is the first study in which a diabetic QTL has been directly demonstrated to be dominant by using congenic strains. | |||||
| 書誌情報 |
Experimental animals en : Experimental animals 巻 57, 号 2, p. 135-138, 発行日 2008-12 |
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| 出版者 | ||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13411357 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11032321 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1538/expanim.57.135 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C)2008 Japanese Association for Laboratory Animal Science | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきJ-Stageから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/expanim/57/2/57_2_135/_pdf | |||||
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Cite as
Kose, Hiroyuki, Yamada, Takahisa, Matsumoto, Kozo, 2008, An OLETF Allele of Hyperglycemic QTL Nidd3/of Is Dominant: Japanese Association for Laboratory Animal Science, 135–138 p.
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