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Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats
http://hdl.handle.net/10191/30608
http://hdl.handle.net/10191/30608a059f9e7-22d2-46e9-8a14-d41df6432381
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
58_2_193-198.pdf (524.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-12-01 | |||||
| タイトル | ||||||
| タイトル | Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats | |||||
| タイトル | ||||||
| タイトル | Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glomerulonephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QTL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | analysis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | WKY rat | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Kose, Hiroyuki
× Kose, Hiroyuki× Sado, Yoshikazu× Yamada, Takahisa× Matsumoto, Kozo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Genetic bases of glomerulonephritis, a major cause of kidney dysfunction in humans and one of the most characteristic complications of autoimmune disorders such as Goodpasture syndrome, are complex. The Wistar-Kyoto (WKY) rat strain is well characterized for its susceptibility to autoantibodies against glomerular basement membrane (GBM), however the molecular mechanisms underlining the phenotype are largely unknown. Here we performed a whole genome scan using a backcross (BC) F1 (WKY × DA) × WKY population, for which the DA rat is a nonsusceptible control strain. We found two significant QTLs on chromosomes 1 and 12, which were involved in elevated levels of proteinuria and kidney weight index, respectively. The relevance of these QTLs with the genetic factors involved in autoimmunity and renal disease is discussed. | |||||
| 書誌情報 |
Experimental animals en : Experimental animals 巻 58, 号 2, p. 193-198, 発行日 2009-12 |
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| 出版者 | ||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13411357 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11032321 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1538/expanim.58.193 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C)2009 Japanese Association for Laboratory Animal Science | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきJ-Stageから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/expanim/58/2/58_2_193/_pdf | |||||
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Cite as
Kose, Hiroyuki, Sado, Yoshikazu, Yamada, Takahisa, Matsumoto, Kozo, 2009, Genetic Mapping Found Major QTLs for Antibody-Induced Glomerulonephritis in WKY Rats: Japanese Association for Laboratory Animal Science, 193–198 p.
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