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Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats
http://hdl.handle.net/10191/30606
http://hdl.handle.net/10191/30606b53d3f1e-c594-48bd-be36-9a3bcdb4bc28
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
60_2_125-132.pdf (524.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2014-12-01 | |||||
| タイトル | ||||||
| タイトル | Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats | |||||
| タイトル | ||||||
| タイトル | Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | congenic rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | epistasis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QTL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | type 2 diabetes | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Fukumura, Tomoe
× Fukumura, Tomoe× Kose, Hiroyuki× Takeda, Chiyo× Kurita, Yuko× Ochiai, Kazuhiko× Yamada, Takahisa× Matsumoto, Kozo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The condition of hyperglycemia results from multiple genetic and environmental factors. In recent years much progress has been made with regards to the search for candidate genes involved in the expression of various common diseases including type 2 diabetes. However less is known about the specific genetic and environmental connections that are important for the development of the disease. In the present study, we used hyperglycemic congenic rats to address this issue. When given a normal diet, two hyperglycemic QTLs (quantitative trait locus), Nidd2/of and Nidd10/of, showed mild obesity and/or increased blood glucose in the oral glucose tolerance test. In a double congenic strain possessing both loci, these indices were not significantly different from those of either single congenic strain. In contrast, the double congenic strain fed a high-calorie diet showed significantly greater body weight than the single congenic strains or normoglycemic control rats. Although postprandial glucose levels of the double congenic rat were not further aggravated even on the high fat diet, it was notable that the postprandial insulin levels were drastically elevated. From these results, we constructed a novel model animal especially for the study of prediabetic hyperinsulemia, in which two QTLs and an additional dietary condition are involved. This may help to shed light on the genetic basis and gene-to-diet interaction during the early stage of type 2 diabetes. | |||||
| 書誌情報 |
Experimental animals en : Experimental animals 巻 60, 号 2, p. 125-132, 発行日 2011-01 |
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| 出版者 | ||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13411357 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11032321 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1538/expanim.60.125 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C)2011 Japanese Association for Laboratory Animal Science | |||||
| 権利 | ||||||
| 権利情報 | 本文データは学協会の許諾に基づきJ-Stageから複製したものである | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| 異版である | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/expanim/60/2/60_2_125/_pdf | |||||
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Fukumura, Tomoe, Kose, Hiroyuki, Takeda, Chiyo, Kurita, Yuko, Ochiai, Kazuhiko, Yamada, Takahisa, Matsumoto, Kozo, 2011, Genetic Interaction between Hyperglycemic QTLs Is Manifested under a High Calorie Diet in OLETF-Derived Congenic Rats: Japanese Association for Laboratory Animal Science, 125–132 p.
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