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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第8号

特発性QT延長症候群における冠動脈内アセチルコリン投与試験および三量体GTP結合タンパク遺伝子の解析

http://hdl.handle.net/10191/46034
http://hdl.handle.net/10191/46034
c7dad787-71b8-4e86-947d-5685d72853eb
名前 / ファイル ライセンス アクション
112(8)_465-476.pdf 112(8)_465-476.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-03
タイトル
タイトル 特発性QT延長症候群における冠動脈内アセチルコリン投与試験および三量体GTP結合タンパク遺伝子の解析
タイトル
言語 en
タイトル 特発性QT延長症候群における冠動脈内アセチルコリン投与試験および三量体GTP結合タンパク遺伝子の解析
言語
言語 jpn
キーワード
主題Scheme Other
主題 long QT syndrome
キーワード
主題Scheme Other
主題 Heterotrimeric GTP binding protein gene
キーワード
主題Scheme Other
主題 mutation
キーワード
主題Scheme Other
主題 RT-PCR
キーワード
主題Scheme Other
主題 direct nucleotide sequencing
キーワード
主題Scheme Other
主題 QT延長症候群
キーワード
主題Scheme Other
主題 三量体GTP結合タンパク遺伝子
キーワード
主題Scheme Other
主題 変異
キーワード
主題Scheme Other
主題 RT-PCR
キーワード
主題Scheme Other
主題 ダイレクトシークエンス
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Intracoronary Acetylcholine Administration and Analysis of Heterotrimeric GTP Binding Protein Gene in Long QT Syndrome
著者 柴, 正美

× 柴, 正美

WEKO 104967

柴, 正美

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著者別名
識別子 104968
識別子Scheme WEKO
姓名 Shiba, Masami
抄録
内容記述タイプ Abstract
内容記述 Abnormal genes were reported in the idiopathic long QT syndrome (LQT) but the pathogenesis and the aggravating factors of the QT interval on the occurrence of life-threatening ventricular tachyarrythmias are to be determined. Following a case report in which intracoronary acetylcholine (ACh) induced QT prolongation, the effect of Ach on the QT interval was studied. QTc interval was significantly prolonged by ACh:0.519±0.029 sec^<1/2> to 0.688±0.067 sec^<1/2> in QT syndrome but not in the healthy control group. We, then, analyzed the gene of G protein in the blood samples from the patients with LQT using RT-PCR followed by direct nucleotide sequencing. One of 12 patients had 129 bp deletion in G protein β3 subunit. Another patient had four point mutations. They showed C to T transition at codon 12, G to T transition at codon 27, C to T transition at codon 53 and C to T transition at codon 60, which substituted cystein (TGC) for arginine (CGC), asparagine (AAT) for lysine (AAG), leucine (CTA for prorine (CCA) and tryptophan (TGG) for arginie (CGG), respectively. Though these changes suspected splicing abnormality and polymorphysm, analysis of the qene of G protein needs to be studied further in a large number of patients with LQT.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 8, p. 465-476, 発行日 1998-08
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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