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Following a case report in which intracoronary acetylcholine (ACh) induced QT prolongation, the effect of Ach on the QT interval was studied. QTc interval was significantly prolonged by ACh\uff1a0.519\u00b10.029 sec^\u003c1/2\u003e to 0.688\u00b10.067 sec^\u003c1/2\u003e in QT syndrome but not in the healthy control group. We, then, analyzed the gene of G protein in the blood samples from the patients with LQT using RT-PCR followed by direct nucleotide sequencing. One of 12 patients had 129 bp deletion in G protein \u03b23 subunit. Another patient had four point mutations. They showed C to T transition at codon 12, G to T transition at codon 27, C to T transition at codon 53 and C to T transition at codon 60, which substituted cystein (TGC) for arginine (CGC), asparagine (AAT) for lysine (AAG), leucine (CTA for prorine (CCA) and tryptophan (TGG) for arginie (CGG), respectively. Though these changes suspected splicing abnormality and polymorphysm, analysis of the qene of G protein needs to be studied further in a large number of patients with LQT.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "104968", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shiba, Masami"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u67f4, \u6b63\u7f8e"}], "nameIdentifiers": [{"nameIdentifier": "104967", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(8)_465-476.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "112(8)_465-476.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16491/files/112(8)_465-476.pdf"}, "version_id": "45b2d5c6-e459-4770-ad72-4dfb51f1b75d"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "long QT syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Heterotrimeric GTP binding protein gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mutation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RT-PCR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "direct nucleotide sequencing", "subitem_subject_scheme": "Other"}, {"subitem_subject": "QT\u5ef6\u9577\u75c7\u5019\u7fa4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4e09\u91cf\u4f53GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u907a\u4f1d\u5b50", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5909\u7570", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RT-PCR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30c0\u30a4\u30ec\u30af\u30c8\u30b7\u30fc\u30af\u30a8\u30f3\u30b9", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7279\u767a\u6027QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u5185\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u6295\u4e0e\u8a66\u9a13\u304a\u3088\u3073\u4e09\u91cf\u4f53GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u907a\u4f1d\u5b50\u306e\u89e3\u6790", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7279\u767a\u6027QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u5185\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u6295\u4e0e\u8a66\u9a13\u304a\u3088\u3073\u4e09\u91cf\u4f53GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u907a\u4f1d\u5b50\u306e\u89e3\u6790"}, {"subitem_title": "\u7279\u767a\u6027QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u5185\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u6295\u4e0e\u8a66\u9a13\u304a\u3088\u3073\u4e09\u91cf\u4f53GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u907a\u4f1d\u5b50\u306e\u89e3\u6790", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1105"], "permalink_uri": "http://hdl.handle.net/10191/46034", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-03"}, "publish_date": "2017-02-03", "publish_status": "0", "recid": "16491", "relation": {}, "relation_version_is_last": true, "title": ["\u7279\u767a\u6027QT\u5ef6\u9577\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u5185\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u6295\u4e0e\u8a66\u9a13\u304a\u3088\u3073\u4e09\u91cf\u4f53GTP\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u907a\u4f1d\u5b50\u306e\u89e3\u6790"], "weko_shared_id": null}