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The common presentation of diabetic neuropathy is chronic, symmetric distal sensory loss and hyporeflexia, which usually occurs in longstanding forms of either type of diabetes. The pathogenesis is multifactorial, such as changes in polyol pathway flux, oxidative stress, non-enzymatic protein glycation, endothelial dysfunction leading to reduced nerve blood flow and deficits in neurotrophic factors. Examination with magnetic resonance spectroscopy revealed that endoneurial edema initiates deterioration of physiological functions in nerve without clinical symptoms, followed by abnormal findings on neurological examination which meant reversibility of the neuropathy in early stages of the diabetic condition. Drugs that improve the nerve micro environment might be benificial in the early phase of neuropathy, whereas in the late stage, drugs that enhance nerve regeneration might restore neurological function.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "104354", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tanaka, Keiko"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7530\u4e2d, \u6075\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "104353", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(10)_607-610.pdf", "filesize": [{"value": "701.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 701600.0, "url": {"label": "112(10)_607-610.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16372/files/112(10)_607-610.pdf"}, "version_id": "6baba8a2-e2d5-4a54-84fa-4fd04f05d711"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "diabetic neuropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autonomic neuropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pathogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pharmacotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u81ea\u5f8b\u795e\u7d4c\u969c\u5bb3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u75c5\u56e0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6cbb\u7642", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "3)\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u6cbb\u7642, \u7b2c535\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "3)\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u6cbb\u7642, \u7b2c535\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"}, {"subitem_title": "3)\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u6cbb\u7642, \u7b2c535\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1103"], "permalink_uri": "http://hdl.handle.net/10191/46254", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-08"}, "publish_date": "2017-02-08", "publish_status": "0", "recid": "16372", "relation": {}, "relation_version_is_last": true, "title": ["3)\u7cd6\u5c3f\u75c5\u6027\u795e\u7d4c\u969c\u5bb3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u306e\u6cbb\u7642, \u7b2c535\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"], "weko_shared_id": null}