{"_buckets": {"deposit": "7873d911-e667-4d94-9f8f-e00a2c74f170"}, "_deposit": {"id": "16296", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16296"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016296"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Development of Extrathymic T cells and Cytokines"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "675", "bibliographicPageStart": "671", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Recent studies demonstrated that murine liver contained extrathymically differentiated T cells. These cells express intermediate (int) level of TCR (CD3) and IL-2R\u03b2 chain. However, it has been unknown about the development of these int TCR cells without requirement of thymus. Here, we investigated how the int TCR cells were differentiated and proliferated. The int TCR cells but not the other peripheral T cells responded to exogenous IL-7 which supported TCR cell differentiation in thymus. Similar to the bone marrow (BM), the liver contained hematopoietic stem cells (c-kit^+Lin^-) which enabled to reconstitute T, B, macrophage and myeloid cells in irradiated SCID mice. In vitro, the hematopoietic stem cells in the liver did not differentiate into the int TCR cells either in the presence of fetal thymus or thymic stromal cells. However liver-derived stromal cells which could produce IL-7 and other cytokines, supported int TCR cell differentiation. On the other hand, those in BM did not develop the int TCR cells in any condition. Taken together, the int TCR cells in the liver are supposed to be developed in situ from the hematopoietic stem cells in the liver in association with some cytokines like IL-7.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "103930", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miyaji, Chikako"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5bae\u8def, \u667a\u9999\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "103929", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(11)_671-675.pdf", "filesize": [{"value": "771.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 771400.0, "url": {"label": "112(11)_671-675.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16296/files/112(11)_671-675.pdf"}, "version_id": "c730d286-3407-48ee-aadb-613cbed1b5e1"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "extrathymic T cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hematopoietic stem cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SCID mouse", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liver primary cultured cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u9020\u8840\u5e79\u7d30\u80de", "subitem_subject_scheme": "Other"}, {"subitem_subject": "SCID\u30de\u30a6\u30b9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u809d\u521d\u4ee3\u57f9\u990a\u7d30\u80de", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "2)\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de\u306e\u5206\u5316\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u57fa\u790e\u3068\u81e8\u5e8a\u5fdc\u7528, \u7b2c537\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "2)\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de\u306e\u5206\u5316\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u57fa\u790e\u3068\u81e8\u5e8a\u5fdc\u7528, \u7b2c537\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"}, {"subitem_title": "2)\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de\u306e\u5206\u5316\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u57fa\u790e\u3068\u81e8\u5e8a\u5fdc\u7528, \u7b2c537\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1102"], "permalink_uri": "http://hdl.handle.net/10191/46333", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-10"}, "publish_date": "2017-02-10", "publish_status": "0", "recid": "16296", "relation": {}, "relation_version_is_last": true, "title": ["2)\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de\u306e\u5206\u5316\u3068\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u57fa\u790e\u3068\u81e8\u5e8a\u5fdc\u7528, \u7b2c537\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a\uff09"], "weko_shared_id": null}