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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第11号

2)胸腺外分化T細胞の分化とサイトカイン(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)

http://hdl.handle.net/10191/46333
http://hdl.handle.net/10191/46333
868d1b83-b655-4af9-bceb-de0cbc7a6a68
名前 / ファイル ライセンス アクション
112(11)_671-675.pdf 112(11)_671-675.pdf (771.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-10
タイトル
タイトル 2)胸腺外分化T細胞の分化とサイトカイン(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
タイトル
言語 en
タイトル 2)胸腺外分化T細胞の分化とサイトカイン(シンポジウム サイトカインの基礎と臨床応用, 第537回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 extrathymic T cells
キーワード
主題Scheme Other
主題 IL-7
キーワード
主題Scheme Other
主題 hematopoietic stem cells
キーワード
主題Scheme Other
主題 SCID mouse
キーワード
主題Scheme Other
主題 liver primary cultured cells
キーワード
主題Scheme Other
主題 胸腺外分化T細胞
キーワード
主題Scheme Other
主題 造血幹細胞
キーワード
主題Scheme Other
主題 SCIDマウス
キーワード
主題Scheme Other
主題 肝初代培養細胞
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Development of Extrathymic T cells and Cytokines
著者 宮路, 智香子

× 宮路, 智香子

WEKO 103929

宮路, 智香子

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著者別名
識別子 103930
識別子Scheme WEKO
姓名 Miyaji, Chikako
抄録
内容記述タイプ Abstract
内容記述 Recent studies demonstrated that murine liver contained extrathymically differentiated T cells. These cells express intermediate (int) level of TCR (CD3) and IL-2Rβ chain. However, it has been unknown about the development of these int TCR cells without requirement of thymus. Here, we investigated how the int TCR cells were differentiated and proliferated. The int TCR cells but not the other peripheral T cells responded to exogenous IL-7 which supported TCR cell differentiation in thymus. Similar to the bone marrow (BM), the liver contained hematopoietic stem cells (c-kit^+Lin^-) which enabled to reconstitute T, B, macrophage and myeloid cells in irradiated SCID mice. In vitro, the hematopoietic stem cells in the liver did not differentiate into the int TCR cells either in the presence of fetal thymus or thymic stromal cells. However liver-derived stromal cells which could produce IL-7 and other cytokines, supported int TCR cell differentiation. On the other hand, those in BM did not develop the int TCR cells in any condition. Taken together, the int TCR cells in the liver are supposed to be developed in situ from the hematopoietic stem cells in the liver in association with some cytokines like IL-7.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 11, p. 671-675, 発行日 1998-11
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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