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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 250 大学院医歯学総合研究科(医)
  2. 10 学術雑誌論文
  3. 10 査読済論文

Association between warfarin use and incidence of ischemic stroke in Japanese hemodialysis patients with chronic sustained atrial fibrillation : a prospective cohort study

http://hdl.handle.net/10191/33051
http://hdl.handle.net/10191/33051
83639afe-1458-45b2-b288-3698c1905ace
名前 / ファイル ライセンス アクション
CEN_18(4)_662-669_tables.pdf tables (50.8 kB)
CEN_18(4)_662-669_figures.pdf figures (231.3 kB)
CEN_18(4)_662-669_manuscript.pdf manuscript (111.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-08-19
タイトル
タイトル Association between warfarin use and incidence of ischemic stroke in Japanese hemodialysis patients with chronic sustained atrial fibrillation : a prospective cohort study
言語
言語 eng
キーワード
主題Scheme Other
主題 Brain Infarction
キーワード
主題Scheme Other
主題 Cohort Studies
キーワード
主題Scheme Other
主題 Hemorrhage
キーワード
主題Scheme Other
主題 Mortality
キーワード
主題Scheme Other
主題 Propensity Score
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Wakasugi, Minako

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Wakasugi, Minako

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Kazama, Junichiro James

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Kazama, Junichiro James

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Tokumoto, Akihide

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Tokumoto, Akihide

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Suzuki, Kensuke

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Suzuki, Kensuke

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Kageyama, Shinji

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Kageyama, Shinji

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Ohya, Kaoru

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Ohya, Kaoru

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Miura, Yoshiaki

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Miura, Yoshiaki

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Kawachi, Mamoru

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Kawachi, Mamoru

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Takata, Takuma

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Takata, Takuma

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Nagai, Masaaki

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Nagai, Masaaki

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Ohya, Minoru

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Ohya, Minoru

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Kutsuwada, Keiko

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Kutsuwada, Keiko

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Okajima, Hideo

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Okajima, Hideo

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Ei, Isei

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Ei, Isei

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Takahashi, Sachio

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Takahashi, Sachio

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Narita, Ichiei

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Narita, Ichiei

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抄録
内容記述タイプ Abstract
内容記述 Background: Although generally recommended for atrial fibrillation (AF) in the general population, the efficacy and safety of warfarin in hemodialysis patients remains controversial. Warfarin use in hemodialysis patients may confer an additional risk of bleeding that is not appreciated in patients without renal failure because hemodialysis patients have platelet defects and receive anticoagulation agents during dialysis. The incidence of major bleeding was reported to be higher in Japanese AF patients on warfarin therapy compared to patients in other countries, suggesting that racial differences may influence bleeding tendency. Thus, examining risks and benefits of warfarin therapy in Japanese hemodialysis patients with AF is important. Methods: To determine associations between warfarin use and new ischemic stroke events, major bleeding, and all-cause mortality, a prospective cohort study of 60 Japanese hemodialysis patients with chronic sustained AF was conducted using Cox proportional modeling and propensity score matching. Results: The mean patient age was 68.1 years. During 110 person-years of follow-up, 13 ischemic strokes occurred. After adjusting for CHADS2 score, warfarin use was not associated with a significant reduction in ischemic stroke events (HR 3.36; 95% CI, 0.94 to 11.23). Similar results were obtained after propensity score matching (HR 3.36; 95% CI, 0.67 to 16.66). Warfarin use was not associated with significant increases in major bleeding or all-cause mortality. Conclusions: These results suggest that warfarin may not prevent ischemic stroke in Japanese hemodialysis patients with chronic sustained AF. Adequately powered studies are needed to determine the risks and benefits of anticoagulation therapy in these patients.
書誌情報 Clinical and experimental nephrology
en : Clinical and experimental nephrology

巻 18, 号 4, p. 662-669, 発行日 2014-08
出版者
出版者 Springer
ISSN
収録物識別子タイプ ISSN
収録物識別子 13421751
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11126935
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1007/s10157-013-0885-6
権利
権利情報 The original publication is available at www.springerlink.com
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