{"_buckets": {"deposit": "42c838a1-b0e5-45f8-acf6-15cff2cee815"}, "_deposit": {"id": "1608", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1608"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00001608", "sets": ["454", "478"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "229", "bibliographicPageStart": "219", "bibliographicVolumeNumber": "325", "bibliographic_titles": [{"bibliographic_title": "Cell and tissue research"}, {"bibliographic_title": "Cell and tissue research", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "It has been assumed that dental pulp has the capacity to elaborate both bone and dentin matrix under the pathological conditions following tooth injury. This study aims to clarify the mechanism to induce bone formation in the dental pulp by investigating the pulpal healing process after tooth replantation using micro-computed tomography (μ-CT), immunocytochemistry for heat-shock protein (HSP)-25 and cathepsin K (CK), and histochemistry for both alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). Under deep anesthesia, the upper right first molar of 4-week-old Wistar rats was extracted and then immediately repositioned in the original socket. In the control teeth at postnatal 4 weeks, the periphery of the coronal dental pulp showed intense ALP- and HSP-25-positive reactions, whereas there were no TRAP- and CK-positive cells. Tooth replantation weakened or terminated ALP- and HSP-25-positive reactions in the pulp tissue at the initial stages. Three to seven days after operation, the ALP-positive region recovered from the root apex to the coronal pulp followed by HSP-25-positive reactions in the successful case that resulted in tertiary dentin formation. In another case, TRAP- and CK-positive cells appeared in the pulp tissue of the replanted tooth at postoperative days 5–10, and remained associated with the bone tissue after 12–60 days. Immunoelectron microscopy clearly demonstrated that CK-positive osteoclast-lineage cells made contact with the mesenchymal cells with prominent nucleoli and developed cell organelles. These data suggest that the appearance of TRAP- and CK-positive cells may be involved in the induction of bone tissue formation in dental pulp.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "14", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "大島, 勇人"}]}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Berlin/Heidelberg"}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1007/s00441-005-0138-4", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Springer-Verlag 2006"}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00600105", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0302766X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsukamoto-Tanaka, Hiroko"}], "nameIdentifiers": [{"nameIdentifier": "4577", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikegame, Mika"}], "nameIdentifiers": [{"nameIdentifier": "4578", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takagi, Ritsuo"}], "nameIdentifiers": [{"nameIdentifier": "4579", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Harada, Hidemitsu"}], "nameIdentifiers": [{"nameIdentifier": "4580", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohshima, Hayato"}], "nameIdentifiers": [{"nameIdentifier": "14", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "9_0004.pdf", "filesize": [{"value": "136.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 136400.0, "url": {"label": "9_0004.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/1608/files/9_0004.pdf"}, "version_id": "18826b2d-71f2-4f4c-99cd-fd8eba913d86"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Bone development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Dental pulp", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Osteoclast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rats (Wistar)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tooth Replantation", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Histochemical and immunocytochemical study on hard tissue formation in dental pulp during the healing process after tooth replantation in rat molars", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Histochemical and immunocytochemical study on hard tissue formation in dental pulp during the healing process after tooth replantation in rat molars"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "478"], "permalink_uri": "http://hdl.handle.net/10191/1807", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "1608", "relation": {}, "relation_version_is_last": true, "title": ["Histochemical and immunocytochemical study on hard tissue formation in dental pulp during the healing process after tooth replantation in rat molars"], "weko_shared_id": 2}