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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 070 農学部
  2. 10 学術雑誌論文
  3. 10 査読済論文

Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle

http://hdl.handle.net/10191/30610
http://hdl.handle.net/10191/30610
8ee10688-c483-45ac-a989-77aa1d2dc4b3
名前 / ファイル ライセンス アクション
2_78.pdf 2_78.pdf (262.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-12-01
タイトル
タイトル Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle
タイトル
言語 en
タイトル Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Yamada, Takahisa

× Yamada, Takahisa

WEKO 4459

Yamada, Takahisa

Search repository
Sasaki, Seiki

× Sasaki, Seiki

WEKO 4460

Sasaki, Seiki

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Sukegawa, Shin

× Sukegawa, Shin

WEKO 4461

Sukegawa, Shin

Search repository
Yoshioka, Sachiyo

× Yoshioka, Sachiyo

WEKO 4462

Yoshioka, Sachiyo

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Takahagi, Youichi

× Takahagi, Youichi

WEKO 4463

Takahagi, Youichi

Search repository
Morita, Mitsuo

× Morita, Mitsuo

WEKO 4464

Morita, Mitsuo

Search repository
Murakami, Hiroshi

× Murakami, Hiroshi

WEKO 4465

Murakami, Hiroshi

Search repository
Morimatsu, Fumiki

× Morimatsu, Fumiki

WEKO 4466

Morimatsu, Fumiki

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Fujita, Tatsuo

× Fujita, Tatsuo

WEKO 4467

Fujita, Tatsuo

Search repository
Miyake, Takeshi

× Miyake, Takeshi

WEKO 4468

Miyake, Takeshi

Search repository
Sasaki, Yoshiyuki

× Sasaki, Yoshiyuki

WEKO 4469

Sasaki, Yoshiyuki

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: Marbling defined by the amount and distribution of intramuscular fat is an economically important trait of beef cattle in Japan. We have recently reported that single nucleotide polymorphisms (SNPs) in the endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 (EDG1) gene were associated with marbling in Japanese Black beef cattle. As well as EDG1, the titin (TTN) gene, involved in myofibrillogenesis, has been previously shown to possess expression difference in musculus longissimus muscle between low-marbled and high-marbled steer groups, and to be located within genomic region of a quantitative trait locus for marbling. Thus TTN was considered as a positional functional candidate for the gene responsible for marbling. In this study, we explored SNP in TTN and analyzed association of the SNP with marbling. Findings: A SNP in the promoter region of TTN, referred to as g.231054C>T, was the only difference detected between high- and low-marbled steer groups. The SNP was associated with marbling in 3 experiments using 101 sires (P= 0.004), 848 paternal half-sib progeny steers from 5 sires heterozygous for the g.231054C>T (P= 0.046), and 820 paternal half-sib progeny steers from 3 sires homozygous for C allele at the g.231054C>T (P= 0.051), in Japanese Black beef cattle. The effect of genotypes of the SNP on subcutaneous fat thickness was not statistically significant (P>0.05). Conclusion: These findings suggest that in addition to the EDG1 SNPs, the TTN SNP polymorphism is associated with marbling and may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle. Further replicate studies will be needed to confirm the allelic association observed here, and to expand the results to evaluate all possible genotypic combinations of alleles.
書誌情報 BMC research notes
en : BMC research notes

巻 2, p. 78-1-78-6, 発行日 2009-05
出版者
出版者 BioMed Central
ISSN
収録物識別子タイプ ISSN
収録物識別子 17560500
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1186/1756-0500-2-78
権利
権利情報 (C) 2009 Sasaki et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版フラグ
値 publisher
異版である
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.biomedcentral.com/content/pdf/1756-0500-2-78.pdf
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