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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第1号

結核菌の化学予防剤イソニアジドへの耐性

http://hdl.handle.net/10191/48031
http://hdl.handle.net/10191/48031
dcd19fb2-f898-4a6c-b8fb-4fae0dbdf2d8
名前 / ファイル ライセンス アクション
115(1)_13-18.pdf 115(1)_13-18.pdf (1.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-07
タイトル
タイトル 結核菌の化学予防剤イソニアジドへの耐性
タイトル
言語 en
タイトル 結核菌の化学予防剤イソニアジドへの耐性
言語
言語 jpn
キーワード
主題Scheme Other
主題 Morcobacterium tubercalosis
キーワード
主題Scheme Other
主題 isoniazid
キーワード
主題Scheme Other
主題 mode of action
キーワード
主題Scheme Other
主題 resistance
キーワード
主題Scheme Other
主題 結核菌
キーワード
主題Scheme Other
主題 イソニアジド
キーワード
主題Scheme Other
主題 作用機序
キーワード
主題Scheme Other
主題 耐性
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Resistance to a Prophylaxis Agent Isoniazid of Mycobacterium tuberculosis
著者 三浦, 智史

× 三浦, 智史

WEKO 96827

三浦, 智史

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著者別名
識別子 96828
識別子Scheme WEKO
姓名 Miura, Tomofumi
抄録
内容記述タイプ Abstract
内容記述 Isoniazid, a synthetic antimicrobial agent, was found to be effective against tuberculosis in 1952 and still remains a valuable drug for the prophlaxis and treatment of Mycobacterium tuberculosis infections. Isoniazid shows its harmful effect on M. tuberculosis through activation by KatG (catalase-peroxidase). The primary target of the activated structure is InhA (NADH-dependent, 2-trans enoyl-acyl carrier protein reductase), whose inactivation results in loss of the precursor to mycolic acid (a major component of the cell wall skeleton) and accumulation of hexacosanoic acid (C26:0), Isoniazid resistance was thus conferred by mutations in the kat G gene as well as inhA gene. Involvement of additional genes such as ahpC (encoding alkyl hydroperoxidase), kasA/B (encoding B-ketoacyl ACP synthase), or ndh (encoding NADH dehydrogenase) have also been proposed. It is considered that the mutations in the katG, inhA, and ahpC genes cover up to 80% of isoniazid resistance of clinical isolates of M. tuberculosis.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 1, p. 13-18, 発行日 2001-01
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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