{"_buckets": {"deposit": "ff87936c-7488-4330-80ad-884676e45f9b"}, "_deposit": {"id": "15055", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15055"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00015055"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Resistance to a Prophylaxis Agent Isoniazid of Mycobacterium tuberculosis"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "18", "bibliographicPageStart": "13", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Isoniazid, a synthetic antimicrobial agent, was found to be effective against tuberculosis in 1952 and still remains a valuable drug for the prophlaxis and treatment of Mycobacterium tuberculosis infections. Isoniazid shows its harmful effect on M. tuberculosis through activation by KatG (catalase-peroxidase). The primary target of the activated structure is InhA (NADH-dependent, 2-trans enoyl-acyl carrier protein reductase), whose inactivation results in loss of the precursor to mycolic acid (a major component of the cell wall skeleton) and accumulation of hexacosanoic acid (C26:0), Isoniazid resistance was thus conferred by mutations in the kat G gene as well as inhA gene. Involvement of additional genes such as ahpC (encoding alkyl hydroperoxidase), kasA/B (encoding B-ketoacyl ACP synthase), or ndh (encoding NADH dehydrogenase) have also been proposed. It is considered that the mutations in the katG, inhA, and ahpC genes cover up to 80% of isoniazid resistance of clinical isolates of M. tuberculosis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "96828", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miura, Tomofumi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e09\u6d66, \u667a\u53f2"}], "nameIdentifiers": [{"nameIdentifier": "96827", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(1)_13-18.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "115(1)_13-18.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/15055/files/115(1)_13-18.pdf"}, "version_id": "b2677c67-900b-41c1-83d6-35d107f81bae"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Morcobacterium tubercalosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "isoniazid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mode of action", "subitem_subject_scheme": "Other"}, {"subitem_subject": "resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7d50\u6838\u83cc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a4\u30bd\u30cb\u30a2\u30b8\u30c9", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u4f5c\u7528\u6a5f\u5e8f", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8010\u6027", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u7d50\u6838\u83cc\u306e\u5316\u5b66\u4e88\u9632\u5264\u30a4\u30bd\u30cb\u30a2\u30b8\u30c9\u3078\u306e\u8010\u6027", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u7d50\u6838\u83cc\u306e\u5316\u5b66\u4e88\u9632\u5264\u30a4\u30bd\u30cb\u30a2\u30b8\u30c9\u3078\u306e\u8010\u6027"}, {"subitem_title": "\u7d50\u6838\u83cc\u306e\u5316\u5b66\u4e88\u9632\u5264\u30a4\u30bd\u30cb\u30a2\u30b8\u30c9\u3078\u306e\u8010\u6027", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1079"], "permalink_uri": "http://hdl.handle.net/10191/48031", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-11-07"}, "publish_date": "2017-11-07", "publish_status": "0", "recid": "15055", "relation": {}, "relation_version_is_last": true, "title": ["\u7d50\u6838\u83cc\u306e\u5316\u5b66\u4e88\u9632\u5264\u30a4\u30bd\u30cb\u30a2\u30b8\u30c9\u3078\u306e\u8010\u6027"], "weko_shared_id": null}