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結核菌の化学予防剤イソニアジドへの耐性
http://hdl.handle.net/10191/48031
dcd19fb2-f898-4a6c-b8fb-4fae0dbdf2d8
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-11-07 | |||||
タイトル | ||||||
タイトル | 結核菌の化学予防剤イソニアジドへの耐性 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 結核菌の化学予防剤イソニアジドへの耐性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Morcobacterium tubercalosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | isoniazid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mode of action | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 結核菌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | イソニアジド | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 作用機序 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 耐性 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Resistance to a Prophylaxis Agent Isoniazid of Mycobacterium tuberculosis | |||||
著者 |
三浦, 智史
× 三浦, 智史 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 96828 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Miura, Tomofumi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Isoniazid, a synthetic antimicrobial agent, was found to be effective against tuberculosis in 1952 and still remains a valuable drug for the prophlaxis and treatment of Mycobacterium tuberculosis infections. Isoniazid shows its harmful effect on M. tuberculosis through activation by KatG (catalase-peroxidase). The primary target of the activated structure is InhA (NADH-dependent, 2-trans enoyl-acyl carrier protein reductase), whose inactivation results in loss of the precursor to mycolic acid (a major component of the cell wall skeleton) and accumulation of hexacosanoic acid (C26:0), Isoniazid resistance was thus conferred by mutations in the kat G gene as well as inhA gene. Involvement of additional genes such as ahpC (encoding alkyl hydroperoxidase), kasA/B (encoding B-ketoacyl ACP synthase), or ndh (encoding NADH dehydrogenase) have also been proposed. It is considered that the mutations in the katG, inhA, and ahpC genes cover up to 80% of isoniazid resistance of clinical isolates of M. tuberculosis. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 1, p. 13-18, 発行日 2001-01 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |