{"_buckets": {"deposit": "ff87936c-7488-4330-80ad-884676e45f9b"}, "_deposit": {"id": "15055", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "15055"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00015055", "sets": ["456", "1079"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Resistance to a Prophylaxis Agent Isoniazid of Mycobacterium tuberculosis"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "18", "bibliographicPageStart": "13", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Isoniazid, a synthetic antimicrobial agent, was found to be effective against tuberculosis in 1952 and still remains a valuable drug for the prophlaxis and treatment of Mycobacterium tuberculosis infections. Isoniazid shows its harmful effect on M. tuberculosis through activation by KatG (catalase-peroxidase). The primary target of the activated structure is InhA (NADH-dependent, 2-trans enoyl-acyl carrier protein reductase), whose inactivation results in loss of the precursor to mycolic acid (a major component of the cell wall skeleton) and accumulation of hexacosanoic acid (C26:0), Isoniazid resistance was thus conferred by mutations in the kat G gene as well as inhA gene. Involvement of additional genes such as ahpC (encoding alkyl hydroperoxidase), kasA/B (encoding B-ketoacyl ACP synthase), or ndh (encoding NADH dehydrogenase) have also been proposed. It is considered that the mutations in the katG, inhA, and ahpC genes cover up to 80% of isoniazid resistance of clinical isolates of M. tuberculosis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "96828", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miura, Tomofumi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "三浦, 智史"}], "nameIdentifiers": [{"nameIdentifier": "96827", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(1)_13-18.pdf", "filesize": [{"value": "1.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1300000.0, "url": {"label": "115(1)_13-18.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/15055/files/115(1)_13-18.pdf"}, "version_id": "b2677c67-900b-41c1-83d6-35d107f81bae"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Morcobacterium tubercalosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "isoniazid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mode of action", "subitem_subject_scheme": "Other"}, {"subitem_subject": "resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "結核菌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "イソニアジド", "subitem_subject_scheme": "Other"}, {"subitem_subject": "作用機序", "subitem_subject_scheme": "Other"}, {"subitem_subject": "耐性", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "結核菌の化学予防剤イソニアジドへの耐性", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "結核菌の化学予防剤イソニアジドへの耐性"}, {"subitem_title": "結核菌の化学予防剤イソニアジドへの耐性", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1079"], "permalink_uri": "http://hdl.handle.net/10191/48031", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-07"}, "publish_date": "2017-11-07", "publish_status": "0", "recid": "15055", "relation": {}, "relation_version_is_last": true, "title": ["結核菌の化学予防剤イソニアジドへの耐性"], "weko_shared_id": null}