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  2. 01 学術雑誌論文
  1. 250 大学院医歯学総合研究科(医)
  2. 10 学術雑誌論文
  3. 10 査読済論文

Association between hypouricemia and reduced kidney function : a cross-sectional population-based study in Japan

http://hdl.handle.net/10191/33291
http://hdl.handle.net/10191/33291
8fc39242-61b3-4432-82a0-d525337024be
名前 / ファイル ライセンス アクション
AJN_41(2)_138-146_SupplementalMaterial.pdf suppl. (201.6 kB)
AJN_41(2)_138-146_figure2.pdf figure2 (58.7 kB)
AJN_41(2)_138-146_figure1.pdf figure1 (38.5 kB)
AJN_41(2)_138-146_tables.pdf tables (124.7 kB)
AJN_41(2)_138-146.pdf AJN_41(2)_138-146.pdf (228.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2015-09-08
タイトル
タイトル Association between hypouricemia and reduced kidney function : a cross-sectional population-based study in Japan
言語
言語 eng
キーワード
主題Scheme Other
主題 uric acid
キーワード
主題Scheme Other
主題 risk factors
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 kidney disease
キーワード
主題Scheme Other
主題 epidemiology
キーワード
主題Scheme Other
主題 diabetes mellitus
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Wakasugi, Minako

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Wakasugi, Minako

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Kazama, Junichiro James

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Kazama, Junichiro James

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Narita, Ichiei

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Narita, Ichiei

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Konta, Tsuneo

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Konta, Tsuneo

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Fujimoto, Shouichi

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Fujimoto, Shouichi

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Iseki, Kunitoshi

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Iseki, Kunitoshi

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Moriyama, Toshiki

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Moriyama, Toshiki

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Yamagata, Kunihiro

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Yamagata, Kunihiro

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Tsuruya, Kazuhiko

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Tsuruya, Kazuhiko

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Asahi, Koichi

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Asahi, Koichi

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Kimura, Kenjiro

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Kimura, Kenjiro

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Kondo, Masahide

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Kondo, Masahide

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Kurahashi, Issei

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Kurahashi, Issei

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Ohashi, Yasuo

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Ohashi, Yasuo

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Watanabe, Tsuyoshi

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Watanabe, Tsuyoshi

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抄録
内容記述タイプ Abstract
内容記述 Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dL, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine the relationship between hypouricemia and reduced kidney function, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m^2. Results: Among 90,710 men (mean age, 63.8 years) and 136,935 women (63.7 years), 193 (0.2%) and 540 (0.4%) were identified as having hypouricemia, respectively. The prevalence of hypouricemia decreased with age in women (P for trend < 0.001), but not in men (P for trend = 0.24). Hypouricemia was associated with reduced kidney function in men (odds ratio, 1.83; 95% confidence interval, 1.23–2.74), but not in women (0.61; 0.43–0.86), relative to the reference category (i.e., serum uric acid levels of 4.1-5.0 mg/dL) after adjusting for age, drinking, smoking, diabetes, hypertension, hypercholesterolemia, obesity, and history of renal failure. Sensitivity analyses stratified by diabetic status yielded similar results. Conclusions: This study is the first to provide evidence that hypouricemia is associated with reduced kidney function in men. Further research will be needed to determine the long-term prognosis of individuals with hypouricemia.
書誌情報 American journal of nephrology
en : American journal of nephrology

巻 41, 号 2, p. 138-146, 発行日 2015-04
出版者
出版者 Karger
ISSN
収録物識別子タイプ ISSN
収録物識別子 02508095
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA10424676
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1159/000381106
権利
権利情報 Copyright(C) 2015 S. Karger AG, Basel
権利
権利情報 The original publication is available at www.karger.com
著者版フラグ
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Cite as

Wakasugi, Minako, Kazama, Junichiro James, Narita, Ichiei, Konta, Tsuneo, Fujimoto, Shouichi, Iseki, Kunitoshi, Moriyama, Toshiki, Yamagata, Kunihiro, Tsuruya, Kazuhiko, Asahi, Koichi, Kimura, Kenjiro, Kondo, Masahide, Kurahashi, Issei, Ohashi, Yasuo, Watanabe, Tsuyoshi, 2015, Association between hypouricemia and reduced kidney function : a cross-sectional population-based study in Japan: Karger, 138–146 p.

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