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Association between hypouricemia and reduced kidney function : a cross-sectional population-based study in Japan
http://hdl.handle.net/10191/33291
http://hdl.handle.net/10191/332918fc39242-61b3-4432-82a0-d525337024be
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AJN_41(2)_138-146.pdf (228.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-09-08 | |||||
| タイトル | ||||||
| タイトル | Association between hypouricemia and reduced kidney function : a cross-sectional population-based study in Japan | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | uric acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | risk factors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxidative stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | kidney disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | epidemiology | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | diabetes mellitus | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Wakasugi, Minako
× Wakasugi, Minako× Kazama, Junichiro James× Narita, Ichiei× Konta, Tsuneo× Fujimoto, Shouichi× Iseki, Kunitoshi× Moriyama, Toshiki× Yamagata, Kunihiro× Tsuruya, Kazuhiko× Asahi, Koichi× Kimura, Kenjiro× Kondo, Masahide× Kurahashi, Issei× Ohashi, Yasuo× Watanabe, Tsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dL, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study using data from the Specific Health Checkups and Guidance System in Japan. Logistic analysis was used to examine the relationship between hypouricemia and reduced kidney function, defined as an estimated glomerular filtration rate <60 mL/min/1.73 m^2. Results: Among 90,710 men (mean age, 63.8 years) and 136,935 women (63.7 years), 193 (0.2%) and 540 (0.4%) were identified as having hypouricemia, respectively. The prevalence of hypouricemia decreased with age in women (P for trend < 0.001), but not in men (P for trend = 0.24). Hypouricemia was associated with reduced kidney function in men (odds ratio, 1.83; 95% confidence interval, 1.23–2.74), but not in women (0.61; 0.43–0.86), relative to the reference category (i.e., serum uric acid levels of 4.1-5.0 mg/dL) after adjusting for age, drinking, smoking, diabetes, hypertension, hypercholesterolemia, obesity, and history of renal failure. Sensitivity analyses stratified by diabetic status yielded similar results. Conclusions: This study is the first to provide evidence that hypouricemia is associated with reduced kidney function in men. Further research will be needed to determine the long-term prognosis of individuals with hypouricemia. | |||||
| 書誌情報 |
American journal of nephrology en : American journal of nephrology 巻 41, 号 2, p. 138-146, 発行日 2015-04 |
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| 出版者 | ||||||
| 出版者 | Karger | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 02508095 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10424676 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1159/000381106 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C) 2015 S. Karger AG, Basel | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.karger.com | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
