{"_buckets": {"deposit": "a8a09b64-8969-4260-ab53-5879a7959031"}, "_deposit": {"id": "1498", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1498"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00001498", "sets": ["454", "478"]}, "author_link": ["4016", "4017", "4018", "4019", "4020"], "control_number": "1498", "item_1627363077551": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "379", "bibliographicPageStart": "371", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Acta histochemica et cytochemica", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "In order to elucidate the causes of ossification in spinal ligaments, ultrastructural alteration and immunolocalization of transforming growth factor-β (TGF-β), as well as that of the TGF-βreceptor were examined during the chondrification of ligamentous fibroblasts, by inducing ossification in ligamenta flava of murine lumbar spines, employing recombinant human bone morphogenetic protein-2 (rhBMP-2). Normal ligamenta flava, consisting of flattened fibroblasts, showed no immunolocalization of TGF-βisoforms. From the second week following BMP-administration, cartilage gradually replaced the ligaments. Cells in the central portion of the ligament contained abundant Golgi apparatus as well as enlarged endoplasmic reticula. Proliferative or hypertrophic chondrocytes in this area showed immunoreactivity to TGF-β3 latency-associated peptide, while calcified hypertrophic chondrocytes accompanied by both matrix vesicleand collagen-calcification were noticed at the insertion site to spinal lamina, where there was no immunolocalization of this peptide. In addition, the TGF-βtype I receptor was localized on the proliferative and hypertrophic cells of the central portion. Therefore, as regards the pathological chondrification of ligamentous fibroblasts induced by exogenous BMP-2, TGF-βis speculated to promote matrix-formation and chondrocytic maturation, under the autocrine/paracrine system, in concert with exogenous BMP-2.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "4020", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "網塚, 憲生", "nameLang": "ja"}]}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本組織細胞化学会"}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://doi.org/10.1267/ahc.30.371", "subitem_relation_type_select": "DOI"}}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508022", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0044-5991", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hoshi, Kazuto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Amizuka, Norio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kurokawa, Takahide", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4018", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozawa, Hidehiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4019", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "7_0002.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2600000.0, "url": {"label": "7_0002.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/1498/files/7_0002.pdf"}, "version_id": "147bb461-78b7-489d-af7a-d43308926396"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Ossification of spinal ligaments", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bone morphogenetic protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transforming growth factor-beta", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immunohistochemistry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fine structure", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "478"], "permalink_uri": "http://hdl.handle.net/10191/5697", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-04-08"}, "publish_date": "2008-04-08", "publish_status": "0", "recid": "1498", "relation": {}, "relation_version_is_last": true, "title": ["Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2"], "weko_shared_id": -1}