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Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2
http://hdl.handle.net/10191/5697
http://hdl.handle.net/10191/56971d26b721-be0b-4c4c-853f-57e489451ca4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
7_0002.pdf (2.6 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ossification of spinal ligaments | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bone morphogenetic protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transforming growth factor-beta | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immunohistochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fine structure | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Hoshi, Kazuto
× Hoshi, Kazuto× Amizuka, Norio× Kurokawa, Takahide× Ozawa, Hidehiro |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 4020 | |||||
| 姓名 | 網塚, 憲生 | |||||
| 言語 | ja | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to elucidate the causes of ossification in spinal ligaments, ultrastructural alteration and immunolocalization of transforming growth factor-β (TGF-β), as well as that of the TGF-βreceptor were examined during the chondrification of ligamentous fibroblasts, by inducing ossification in ligamenta flava of murine lumbar spines, employing recombinant human bone morphogenetic protein-2 (rhBMP-2). Normal ligamenta flava, consisting of flattened fibroblasts, showed no immunolocalization of TGF-βisoforms. From the second week following BMP-administration, cartilage gradually replaced the ligaments. Cells in the central portion of the ligament contained abundant Golgi apparatus as well as enlarged endoplasmic reticula. Proliferative or hypertrophic chondrocytes in this area showed immunoreactivity to TGF-β3 latency-associated peptide, while calcified hypertrophic chondrocytes accompanied by both matrix vesicleand collagen-calcification were noticed at the insertion site to spinal lamina, where there was no immunolocalization of this peptide. In addition, the TGF-βtype I receptor was localized on the proliferative and hypertrophic cells of the central portion. Therefore, as regards the pathological chondrification of ligamentous fibroblasts induced by exogenous BMP-2, TGF-βis speculated to promote matrix-formation and chondrocytic maturation, under the autocrine/paracrine system, in concert with exogenous BMP-2. | |||||
| 書誌情報 |
en : Acta histochemica et cytochemica 巻 30, 号 4, p. 371-379, 発行日 1997 |
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| 出版者 | ||||||
| 出版者 | 日本組織細胞化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0044-5991 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508022 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.1267/ahc.30.371 | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Hoshi, Kazuto, Amizuka, Norio, Kurokawa, Takahide, Ozawa, Hidehiro, 1997, Ultrastructure and Immunolocalization of Transforming Growth Factor-Beta in Chondrification of Murine Ligamentous Fibroblasts and Endochondral Calcification Induced by Recombinant Human Bone Morphogenetic Protein-2: 日本組織細胞化学会, 371–379 p.
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