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Immunohistochemical Localization of Calcitonin Receptor in Mouse Tibiae
http://hdl.handle.net/10191/1810
http://hdl.handle.net/10191/1810c168ccd1-503b-4b6d-b04c-7219cc51c0a2
名前 / ファイル | ライセンス | アクション |
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10_0001.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Immunohistochemical Localization of Calcitonin Receptor in Mouse Tibiae | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunohistochemical Localization of Calcitonin Receptor in Mouse Tibiae | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Osteoclast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcitonin receptor (CTR) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunohistochemistry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunoelectron microscopy | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Izumi, Naoya
× Izumi, Naoya× Amizuka, Norio× Sakakura, Yasunori× Irie, Kazuharu× Yajima, Toshihiko× Ozawa, Hidehiro |
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著者別名 | ||||||
識別子 | 3996 | |||||
識別子Scheme | WEKO | |||||
姓名 | 泉, 直也 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have raised specific antisera against the extracellular domain of the rat/mouse calcitonin receptor (CTR), consequently immunolocalizing the CTR-positive cells in mouse tibiae. As expected, the immuno-reactivity for the CTR was intensely detected in cells identical to tartrateresistant acid phosphatase (TRAP) positive multinucleated osteoclasts and mononuclear cells, whereas no immunoreactivity was detected in osteoblasts and bone marrow cells. Most osteoclasts on the bone surface possessed the CTR, therefore indicating that bone resorbing osteoclasts could be prompted to respond to endogenous calcitonin. Immuno-electron microscopy revealed CTR-immuno-reactivity mainly on the plasma membranes including the pits associated with the cell membranes, and sometimes on intracellular translucent vacuoles and in the vesicles in the osteoclasts. These results lead to the postulation that CTR is chiefly localized to the cell surface of osteoclast, but is subjectde to continuous internalization followed by the receptor-transport to the Golgi apparatus. | |||||
書誌情報 |
Acta histochemica et cytochemica en : Acta histochemica et cytochemica 巻 34, 号 5, p. 363-369, 発行日 2001 |
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出版者 | ||||||
出版者 | Japan Society of Histochemistry and Cytochemistry | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475800 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508022 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1267/ahc.34.363 | |||||
権利 | ||||||
権利情報 | Japan Society of Histochemistry and Cytochemistry | |||||
著者版フラグ | ||||||
値 | publisher |