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Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies
http://hdl.handle.net/10191/6165
http://hdl.handle.net/10191/616565ac34b4-a48a-41bf-ba3b-381faba37bcf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
7_0001.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies | |||||
| タイトル | ||||||
| タイトル | Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mechano-hyperalgesia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | von Frey test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | c-Fos | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MOR | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Ueda, Masashi
× Ueda, Masashi× Hirose, Munetaka× Takei, Nobuyuki× Ibuki, Takae× Naruse, Yoshihisa× Ibata, Yasuhiko× Tanaka, Masaki |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 3989 | |||||
| 姓名 | 武井, 延之 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Using behavioral, immunohistochemical and pharmacological studies, we report here that large thoracic burn injuries remotely induce hindpaw hyperalgesia during the healing stage. During 2-3 weeks after thoracic burn injury when the skin was regenerating from the wound, we observed by formalin test that the number of flinching behaviors significantly increased and simultaneously we observed by von Frey test that rats developed mechano-hyper-algesia in the foot. In the dorsal horn of the lumber spinal cord in burn injured rats, c-Fos expression was significantly augmented after plantar formalin injection. The expression of μ-opioid receptor in burn injured rats was significantly decreased compared with that in sham operated rats. The expression of substance P and CGRP in the lumbar dorsal horn was not different between burn and sham operated animals. We also observed that intrathecal administration of glutamate receptor antagonists(MK801 and CNQX)but not cyclooxigenase-2 an-tagonist(NS-398)reversed the threshold of von Frey test on the foot up to the control level at 2 weeks after injury. Collectively, we analyzed a new pain model showing foot hyperalgesia after thoracic burn injury and demonstrated that neurotransmission of glutamate was enhanced at the lumbar spinal cord level by immunocytochemistry and intrathecal administration of NMDA and non NMDA antagonists. Although the precise mechanism of how remote hyperalgesia at the healing stage developed in this model remains to be confirmed, substances such as trophic factors released from the regenerating skin may cause systemic hyperalgesia including in the foot. | |||||
| 書誌情報 |
Acta histochemica et cytochemica en : Acta histochemica et cytochemica 巻 34, 号 6, p. 441-450, 発行日 2001 |
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| 出版者 | ||||||
| 出版者 | 日本組織細胞化学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00445991 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508022 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1267/ahc.34.441 | |||||
| 権利 | ||||||
| 権利情報 | 日本組織細胞化学会 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Ueda, Masashi, Hirose, Munetaka, Takei, Nobuyuki, Ibuki, Takae, Naruse, Yoshihisa, Ibata, Yasuhiko, Tanaka, Masaki, 2001, Foot Hyperalgesia after Thoracic Burn Injury : Histochemical, Behavioral and Pharmacological Studies: 日本組織細胞化学会, 441–450 p.
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