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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第6号

先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に

http://hdl.handle.net/10191/48255
http://hdl.handle.net/10191/48255
b54af38d-ca64-4f37-9cbf-ddaa3550d791
名前 / ファイル ライセンス アクション
115(6)_245-256.pdf 115(6)_245-256.pdf (2.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-09
タイトル
タイトル 先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に
タイトル
言語 en
タイトル 先天性QT延長症候群の不整脈基盤の成り立ち : 冠動脈内アセチルコリン負荷の心内不応期分布に対する影響を中心に
言語
言語 jpn
キーワード
主題Scheme Other
主題 Long QT Syndrome
キーワード
主題Scheme Other
主題 M-cell
キーワード
主題Scheme Other
主題 acetylcholine
キーワード
主題Scheme Other
主題 QT延長症候群
キーワード
主題Scheme Other
主題 M細胞
キーワード
主題Scheme Other
主題 アセチルコリン
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Tridimensional Ventricular Analysis of Arrhythmogenecity of Long QT Syndrome(Differential effect of intracoronary acetylcholine injection in clinical cases and experimental models)
著者 笠井, 英裕

× 笠井, 英裕

WEKO 95811

笠井, 英裕

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著者別名
識別子 95812
識別子Scheme WEKO
姓名 Kasai, Hidehiro
抄録
内容記述タイプ Abstract
内容記述 Intracoronary administration of acetylcholine (Ach) induced QTc interval prolongation in all 14 patients with congenital long QT syndrome (LQTS) and torsade de pointes arrhythmia developed following premature ventricular beats in 5 of the patients. In the experimental models of LQT 2 and LQT 3, tridimensional repolarization mapping showed that three layers having a different electrophysiological character existed in the left ventricle; endocardial (End), midmyocardial M-cell (Mid) and epicardial layer (Epi). The refractory period estimated by the activation-recovery interval (ARI) in the Mid layer was longer than that at Epi/End layers, so marked transmural ARI dispersion was created especially between the Mid and Epi layers at the longer basic drive of 60 bpm. The marked transmural dispersion of repolarization was diminished when the pacing rate changed to 100 bpm. Different from the clinical LQTS patients, intracoronary Ach administration in the LQT models did not show any QTc interval prolongation at lower concentrations. Further, at higher concentrations (>5μg) of Ach, the Epi layer showed greater ARI abbreviation rather than the Mid/End layers which resulted in greater transmural dispersion of repolarization, but no ventricular arrhythmia was induced.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 6, p. 245-256, 発行日 2001-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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