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Ultrasonography has achieved the premier position for the noninvasive diagnosis of DVT. This examination has become useful both as a screening tool in high-risk patients and for staging patients with known DVT. DVT and PE should be viewed as a continuous spectrum of a single disease. In order to prevent life threatening complications, four therapeutic strategies are available: anticoagulation with heparin, thrombolysis, surgical embolectomy, and interruption of the inferior vena cava. 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