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It triggers a signal transduction process in mammalian cells that leads to cytoskeltal rearrangment. The bacterial proteins responsible for the invasion process have been studied by a comparison of the genome sequences between M. tuberculosis and M. bovis BCG. The genome sequences (including insertion sequences) are important targets for molecular diagnosis. Drug resistance, e. g., nearly 80% of resistance to isoniazid (a prophylaxis agent), can now be diagnosed based on DNA techniques. 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