{"_buckets": {"deposit": "a1d546cd-7791-4f49-890c-3cc7ae6977b1"}, "_deposit": {"id": "14723", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14723"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014723", "sets": ["456", "1071"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Phase I Dose Escalation Study of Multicyclic, Dose-Intensive Chemotherapy with Peripheral Blood Stem Cell Support for Small Cell Lung Cancer"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "437", "bibliographicPageStart": "432", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A phase I dose-escalation study of multicyclic, ifosfamide, carboplatin, and etoposide (ICE) with sequential reinfusion of peripheral blood stem-cells (PBSCs) was conducted to determine the maximum-tolerated dose (MTD) of ICE. Twenty-seven patients with SCLC (LD : 9, ED : 18) were treated with ifosfamide (3000-9000mg/m^2, 24-hour-infusion), carboplatin (300-400mg/m^2), and etoposide (300mg/m^2) followed by subcutaneous injection of filgrastim (75μg/day) through day 4 to the day of PBSC collection. PBSC were harvested when the WBC count reached ≧5×10^9/L. The leukapheresis product was cryopreserved and reinfused on day 4 of the next cycle, which was started 48 hours after the last PBSC collection. The ifosfamide dose was escalated as follows : 3000mg/m^2 (level 1), 5000mg/m^2 (level 2), 7000mg/m^2 (level 3), 9000mg/m^2 (level 4). Patients with LD were treated with concurrent radiotherapy at 1.5 Gy twice daily for the initial 3 weeks to a total dose of 45Gy and MTD, defined separately. Patients were evaluated for hematologic and non-hematologic toxicity, actual dose intensities, as well as response to the therapy. The maximum-tolerated dose (MTD) was defined as the dose level at which the level produced more than 5 days of grade 4 myelosuppression or non-hematologic toxicity greater than grade 3 in two thirds of the patients. For ED cases, MTD was level 4 and the recommended dose of ifosfamide was 7000mg/m^2. For LD cases, the recommended dose of ifosfamide was 5000mg/m^2. The dose limiting toxicity of multicyclic ICE was hematologic toxicity and CNS toxicity which manifested as ataxia. Tumor responses were seen in all patients, with 14 patients showing a complete response. The actual total dose-intensity at the recommended dose level was 2.2 and 1.74, for ED and LD, respectively, compared with previously reported ICE regimens. PBSC support for dose-intensive ICE regimen permitted dose escalation of ifosfamide with a mean interval of 16-17 days. We conclude this regimen is well tolerated, with acceptable hematological and non-hematological toxicity.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "94977", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yoshizawa, Hirohisa"}]}, {"nameIdentifiers": [{"nameIdentifier": "94978", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Matsumoto, Naoya"}]}, {"nameIdentifiers": [{"nameIdentifier": "94979", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mochizuki, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "94980", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kuriyama, Hideyuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "94981", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kagamu, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "94982", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Suzuki, Eiichi"}]}, {"nameIdentifiers": [{"nameIdentifier": "94983", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Gejyo, Fumitake"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "吉澤, 弘久"}], "nameIdentifiers": [{"nameIdentifier": "94970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "松本, 尚也"}], "nameIdentifiers": [{"nameIdentifier": "94971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "望月, 博史"}], "nameIdentifiers": [{"nameIdentifier": "94972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "栗山, 英之"}], "nameIdentifiers": [{"nameIdentifier": "94973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "各務, 博"}], "nameIdentifiers": [{"nameIdentifier": "94974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "鈴木, 栄一"}], "nameIdentifiers": [{"nameIdentifier": "94975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "下条, 文武"}], "nameIdentifiers": [{"nameIdentifier": "94976", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(9)_432-437.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "115(9)_432-437.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14723/files/115(9)_432-437.pdf"}, "version_id": "800a2eeb-27ec-4133-a576-034f245cb1b1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Small cell lung cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Dose intensive chemotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Granulocyte Colony-Stimulating Factor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hematopoietic Stem Cell Transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Leukapheresis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "小細胞肺癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "高用量化学療法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "顆粒球コロニー刺激因子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "造血幹細胞移植", "subitem_subject_scheme": "Other"}, {"subitem_subject": "幹細胞採取", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "2）小細胞肺癌に対する末梢血幹細胞移植併用(シンポジウム 移植医療の現況, 第551回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "2）小細胞肺癌に対する末梢血幹細胞移植併用(シンポジウム 移植医療の現況, 第551回新潟医学会)"}, {"subitem_title": "2）小細胞肺癌に対する末梢血幹細胞移植併用(シンポジウム 移植医療の現況, 第551回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1071"], "permalink_uri": "http://hdl.handle.net/10191/48382", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-09"}, "publish_date": "2017-11-09", "publish_status": "0", "recid": "14723", "relation": {}, "relation_version_is_last": true, "title": ["2）小細胞肺癌に対する末梢血幹細胞移植併用(シンポジウム 移植医療の現況, 第551回新潟医学会)"], "weko_shared_id": null}