{"_buckets": {"deposit": "a1d546cd-7791-4f49-890c-3cc7ae6977b1"}, "_deposit": {"id": "14723", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14723"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014723"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Phase I Dose Escalation Study of Multicyclic, Dose-Intensive Chemotherapy with Peripheral Blood Stem Cell Support for Small Cell Lung Cancer"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "437", "bibliographicPageStart": "432", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "A phase I dose-escalation study of multicyclic, ifosfamide, carboplatin, and etoposide (ICE) with sequential reinfusion of peripheral blood stem-cells (PBSCs) was conducted to determine the maximum-tolerated dose (MTD) of ICE. Twenty-seven patients with SCLC (LD : 9, ED : 18) were treated with ifosfamide (3000-9000mg/m^2, 24-hour-infusion), carboplatin (300-400mg/m^2), and etoposide (300mg/m^2) followed by subcutaneous injection of filgrastim (75\u03bcg/day) through day 4 to the day of PBSC collection. PBSC were harvested when the WBC count reached \u22675\u00d710^9/L. The leukapheresis product was cryopreserved and reinfused on day 4 of the next cycle, which was started 48 hours after the last PBSC collection. The ifosfamide dose was escalated as follows : 3000mg/m^2 (level 1), 5000mg/m^2 (level 2), 7000mg/m^2 (level 3), 9000mg/m^2 (level 4). Patients with LD were treated with concurrent radiotherapy at 1.5 Gy twice daily for the initial 3 weeks to a total dose of 45Gy and MTD, defined separately. Patients were evaluated for hematologic and non-hematologic toxicity, actual dose intensities, as well as response to the therapy. The maximum-tolerated dose (MTD) was defined as the dose level at which the level produced more than 5 days of grade 4 myelosuppression or non-hematologic toxicity greater than grade 3 in two thirds of the patients. For ED cases, MTD was level 4 and the recommended dose of ifosfamide was 7000mg/m^2. For LD cases, the recommended dose of ifosfamide was 5000mg/m^2. The dose limiting toxicity of multicyclic ICE was hematologic toxicity and CNS toxicity which manifested as ataxia. Tumor responses were seen in all patients, with 14 patients showing a complete response. The actual total dose-intensity at the recommended dose level was 2.2 and 1.74, for ED and LD, respectively, compared with previously reported ICE regimens. PBSC support for dose-intensive ICE regimen permitted dose escalation of ifosfamide with a mean interval of 16-17 days. We conclude this regimen is well tolerated, with acceptable hematological and non-hematological toxicity.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "94977", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yoshizawa, Hirohisa"}]}, {"nameIdentifiers": [{"nameIdentifier": "94978", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Matsumoto, Naoya"}]}, {"nameIdentifiers": [{"nameIdentifier": "94979", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mochizuki, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "94980", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kuriyama, Hideyuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "94981", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kagamu, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "94982", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Suzuki, Eiichi"}]}, 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