WEKO3
アイテム
脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違
http://hdl.handle.net/10191/48427
http://hdl.handle.net/10191/48427fc15cad9-538f-4c34-ab3e-a6f5f7c9b963
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
115(10)_518-527.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-11-09 | |||||
| タイトル | ||||||
| タイトル | 脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違 | |||||
| タイトル | ||||||
| タイトル | 脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA receptor channel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GluRε 2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GluRε 4 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | homologous recombination | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | spontaneous activity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA受容体チャネル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 相同組換え | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 自発的活動性 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Functional Difference Between ε2 and ε4 Subunits of NMDA Receptor Channel in the Developmental Mouse Brain | |||||
| 著者 |
柿崎, 利和
× 柿崎, 利和 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 94614 | |||||
| 姓名 | Kakizaki, Toshikazu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor (GluR) channel plays roles in synaptic plasticity as a molecular coincident detector and in neuronal pattern formation during development. NMDA receptor channels are composed of the GluRε (NR 2) and GluRζ (NR 1) subunits. There are four GluRε subunit genes, although GluRζ subunit variants are derived from a single gene. The molecular composition of NMDA receptor channels varies depending on the location and developmental stage of brain. At the embryonic stage, GluRε 2 mRNA is expressed in the entire brain, while GluRε 4 mRNA is expressed only in the diencephalon and brainstem. Therefore, I focused on the GluRε 2 and GluRε 4 subunits to determine their functions during development. I produced a mutant mouse line (ε 4-E2), which expressed GluRε 2 protein under the GluRε 4 gene promoter, by inserting ε 2 cDNA into GluRε 4 subunit gene with the homologous recombination. In this mutant mice, I found GluRε 2 appeared instead of GluRε 4, and compared its behavioral phenotype with that of the GluRε 4 knockout mouse. Theε 4-E2 mutant mice showed a significantly lower spontaneous activity than that of the GluRε 4 knockout mice. On the other hand, there was no significant difference in the spontaneous activity between the GluRε 4 mutant mice and wild-type mice. These results suggest that the GluRε 2 and GluRε 4 are distinct in functional properties and GluRε 2 cannot compensate the function of GluRε 4. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 115, 号 10, p. 518-527, 発行日 2001-10 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
