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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第10号

脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違

http://hdl.handle.net/10191/48427
http://hdl.handle.net/10191/48427
fc15cad9-538f-4c34-ab3e-a6f5f7c9b963
名前 / ファイル ライセンス アクション
115(10)_518-527.pdf 115(10)_518-527.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-09
タイトル
タイトル 脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違
タイトル
言語 en
タイトル 脳発達時期に発現するNMDA受容体チャネルε2, ε4サブユニットの機能的差違
言語
言語 jpn
キーワード
主題Scheme Other
主題 NMDA receptor channel
キーワード
主題Scheme Other
主題 GluRε 2
キーワード
主題Scheme Other
主題 GluRε 4
キーワード
主題Scheme Other
主題 homologous recombination
キーワード
主題Scheme Other
主題 spontaneous activity
キーワード
主題Scheme Other
主題 NMDA受容体チャネル
キーワード
主題Scheme Other
主題 相同組換え
キーワード
主題Scheme Other
主題 自発的活動性
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Functional Difference Between ε2 and ε4 Subunits of NMDA Receptor Channel in the Developmental Mouse Brain
著者 柿崎, 利和

× 柿崎, 利和

WEKO 94613

柿崎, 利和

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著者別名
識別子 94614
識別子Scheme WEKO
姓名 Kakizaki, Toshikazu
抄録
内容記述タイプ Abstract
内容記述 The N -methyl-D-aspartate (NMDA) subtype of the glutamate receptor (GluR) channel plays roles in synaptic plasticity as a molecular coincident detector and in neuronal pattern formation during development. NMDA receptor channels are composed of the GluRε (NR 2) and GluRζ (NR 1) subunits. There are four GluRε subunit genes, although GluRζ subunit variants are derived from a single gene. The molecular composition of NMDA receptor channels varies depending on the location and developmental stage of brain. At the embryonic stage, GluRε 2 mRNA is expressed in the entire brain, while GluRε 4 mRNA is expressed only in the diencephalon and brainstem. Therefore, I focused on the GluRε 2 and GluRε 4 subunits to determine their functions during development. I produced a mutant mouse line (ε 4-E2), which expressed GluRε 2 protein under the GluRε 4 gene promoter, by inserting ε 2 cDNA into GluRε 4 subunit gene with the homologous recombination. In this mutant mice, I found GluRε 2 appeared instead of GluRε 4, and compared its behavioral phenotype with that of the GluRε 4 knockout mouse. Theε 4-E2 mutant mice showed a significantly lower spontaneous activity than that of the GluRε 4 knockout mice. On the other hand, there was no significant difference in the spontaneous activity between the GluRε 4 mutant mice and wild-type mice. These results suggest that the GluRε 2 and GluRε 4 are distinct in functional properties and GluRε 2 cannot compensate the function of GluRε 4.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 10, p. 518-527, 発行日 2001-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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