ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "7656d288-9798-4809-bce5-fc451e6656b9"}, "_deposit": {"id": "14656", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14656"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014656", "sets": ["456", "1070"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "A Study on Pathomechanisms of Paraneoplastic Neurological Syndrome"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "505", "bibliographicPageStart": "501", "bibliographicVolumeNumber": "115", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Paraneoplastic neurological syndrome is thought to be caused by an autoimmune mechanism triggered by tumor antigens which attack the neurons presenting the common antigens. We tried to prove the antibody-mediated neuronal loss by passive transfer with IgG containing Yo antibody or Hu antibody and by active immunization with recombinant Yo protein or Hu protein, which was concluded the antibodies per se could not cause neuronal loss. On the other hand, the patients with paraneoplastic neurological syndrome show pleocytosis in the cerebrospinal fruid and massive lymphorrhage, predominant CD8 +T cells, are seen in the tumor and in the affected lesions in the central nervous system. Another observation that each of the patients’ group with anti-Yo antibody positive paraneoplastic cerebellar degeneration or anti-Hu positive sensory neuronopathy have the common HLA class I supertype, that suggested the neuronal loss might be caused by class I restricted CD 8-positive cytotoxic T lymphocytes (CTL). We synthesized the peptides from Yo or Hu protein with binding capacity to each of the class I molecules. We found the CTL activities in the peripheral CD8 +T cells against the matched peptide-presenting autologous fibroblasts. We need to prove the CTL attacks neurons directly.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "94610", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tanaka, Keiko"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "田中, 惠子"}], "nameIdentifiers": [{"nameIdentifier": "94609", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "115(10)_501-505.pdf", "filesize": [{"value": "869.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 869200.0, "url": {"label": "115(10)_501-505.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14656/files/115(10)_501-505.pdf"}, "version_id": "99020abc-d257-4f54-b3f8-7287e8700faf"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "parneoplastic neurological syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Yo antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hu antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD 8+T cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CTL", "subitem_subject_scheme": "Other"}, {"subitem_subject": "傍腫瘍性神経症候群", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Yo抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hu抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD8陽性T細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞傷害性T細胞", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "傍腫瘍性神経症候群の病態機序解明に向けて", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "傍腫瘍性神経症候群の病態機序解明に向けて"}, {"subitem_title": "傍腫瘍性神経症候群の病態機序解明に向けて", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1070"], "permalink_uri": "http://hdl.handle.net/10191/48429", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-11-09"}, "publish_date": "2017-11-09", "publish_status": "0", "recid": "14656", "relation": {}, "relation_version_is_last": true, "title": ["傍腫瘍性神経症候群の病態機序解明に向けて"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第115巻第10号

傍腫瘍性神経症候群の病態機序解明に向けて

http://hdl.handle.net/10191/48429
http://hdl.handle.net/10191/48429
24c4b2c0-1480-4697-86af-f7ac263aa564
名前 / ファイル ライセンス アクション
115(10)_501-505.pdf 115(10)_501-505.pdf (869.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-11-09
タイトル
タイトル 傍腫瘍性神経症候群の病態機序解明に向けて
タイトル
言語 en
タイトル 傍腫瘍性神経症候群の病態機序解明に向けて
言語
言語 jpn
キーワード
主題Scheme Other
主題 parneoplastic neurological syndrome
キーワード
主題Scheme Other
主題 Yo antibody
キーワード
主題Scheme Other
主題 Hu antibody
キーワード
主題Scheme Other
主題 CD 8+T cells
キーワード
主題Scheme Other
主題 CTL
キーワード
主題Scheme Other
主題 傍腫瘍性神経症候群
キーワード
主題Scheme Other
主題 Yo抗体
キーワード
主題Scheme Other
主題 Hu抗体
キーワード
主題Scheme Other
主題 CD8陽性T細胞
キーワード
主題Scheme Other
主題 細胞傷害性T細胞
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル A Study on Pathomechanisms of Paraneoplastic Neurological Syndrome
著者 田中, 惠子

× 田中, 惠子

WEKO 94609

田中, 惠子

Search repository
著者別名
識別子 94610
識別子Scheme WEKO
姓名 Tanaka, Keiko
抄録
内容記述タイプ Abstract
内容記述 Paraneoplastic neurological syndrome is thought to be caused by an autoimmune mechanism triggered by tumor antigens which attack the neurons presenting the common antigens. We tried to prove the antibody-mediated neuronal loss by passive transfer with IgG containing Yo antibody or Hu antibody and by active immunization with recombinant Yo protein or Hu protein, which was concluded the antibodies per se could not cause neuronal loss. On the other hand, the patients with paraneoplastic neurological syndrome show pleocytosis in the cerebrospinal fruid and massive lymphorrhage, predominant CD8 +T cells, are seen in the tumor and in the affected lesions in the central nervous system. Another observation that each of the patients’ group with anti-Yo antibody positive paraneoplastic cerebellar degeneration or anti-Hu positive sensory neuronopathy have the common HLA class I supertype, that suggested the neuronal loss might be caused by class I restricted CD 8-positive cytotoxic T lymphocytes (CTL). We synthesized the peptides from Yo or Hu protein with binding capacity to each of the class I molecules. We found the CTL activities in the peripheral CD8 +T cells against the matched peptide-presenting autologous fibroblasts. We need to prove the CTL attacks neurons directly.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 115, 号 10, p. 501-505, 発行日 2001-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 16:19:35.191970
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3