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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第116巻第7号

アルポート症候群モデルマウスに対する薬物療法の検討

http://hdl.handle.net/10191/2651
http://hdl.handle.net/10191/2651
4e74a3ea-c90e-441d-b7e0-b715e666ac33
名前 / ファイル ライセンス アクション
KJ00000141921.pdf KJ00000141921.pdf (2.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル アルポート症候群モデルマウスに対する薬物療法の検討
タイトル
言語 en
タイトル アルポート症候群モデルマウスに対する薬物療法の検討
言語
言語 jpn
キーワード
主題Scheme Other
主題 Alport syndrome
キーワード
主題Scheme Other
主題 knockout mice
キーワード
主題Scheme Other
主題 cyclosporin A
キーワード
主題Scheme Other
主題 angiotensin converting enzyme inhibitor
キーワード
主題Scheme Other
主題 tenascin-C
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Effects of Two Immunosuppressants, Cyclosporin A and Mizoribime, and Angiotansin Converting Enzyme Inhibitor, Enalapril on Alport Model Mice
著者 伊東, 達雄

× 伊東, 達雄

WEKO 92635

伊東, 達雄

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抄録
内容記述タイプ Abstract
内容記述 Effective pharmacotherapy in Alport syndrome has not yet been established. In this study, the efficiency of two immunosuppressants cyclosporin A (CyA) and mizoribine (MZR), and angiotensin converting enzyme inhibitor (ACEi), enalapril was examined using Col4 α 4 knockout mice as a model of this disease. CyA (10mg/kg/day), MZR (50mg/kg/day) and enalapril (18mg/kg/day) were administered everyday from three weeks of age. The CyA and enalapril treatments suppressed the elevation of proteinuria at 8 and 12 weeks of age and significantly inhibited the crescent formation at 12 weeks of age. The enalapril treatment could prolong the lives of Col4 α 4 mutant mice significantly, i.e, 26.3±6.2 weeks (mean±SD) of the treated mice vs. 18.3±3.9 weeks of the untreated control mice, whereas the CyA treatment failed to prolong the life span. Taken together, enalapril is considered to have a beneficial effect on the Alport model mice. This effect may be brought about by the improvement of renal hemodynamics and the suppression of an antiadhesion factor tenascin.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 116, 号 7, p. 324-336, 発行日 2002-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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