{"_buckets": {"deposit": "060a9f71-3111-4557-8c75-59dd9d785cbe"}, "_deposit": {"id": "14271", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "14271"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00014271", "sets": ["456", "1061"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Two Immunosuppressants, Cyclosporin A and Mizoribime, and Angiotansin Converting Enzyme Inhibitor, Enalapril on Alport Model Mice"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "336", "bibliographicPageStart": "324", "bibliographicVolumeNumber": "116", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Effective pharmacotherapy in Alport syndrome has not yet been established. In this study, the efficiency of two immunosuppressants cyclosporin A (CyA) and mizoribine (MZR), and angiotensin converting enzyme inhibitor (ACEi), enalapril was examined using Col4 α 4 knockout mice as a model of this disease. CyA (10mg/kg/day), MZR (50mg/kg/day) and enalapril (18mg/kg/day) were administered everyday from three weeks of age. The CyA and enalapril treatments suppressed the elevation of proteinuria at 8 and 12 weeks of age and significantly inhibited the crescent formation at 12 weeks of age. The enalapril treatment could prolong the lives of Col4 α 4 mutant mice significantly, i.e, 26.3±6.2 weeks (mean±SD) of the treated mice vs. 18.3±3.9 weeks of the untreated control mice, whereas the CyA treatment failed to prolong the life span. Taken together, enalapril is considered to have a beneficial effect on the Alport model mice. This effect may be brought about by the improvement of renal hemodynamics and the suppression of an antiadhesion factor tenascin.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "伊東, 達雄"}], "nameIdentifiers": [{"nameIdentifier": "92635", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000141921.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "KJ00000141921.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/14271/files/KJ00000141921.pdf"}, "version_id": "3e35d51a-8f09-4d4a-b5af-46172d50909f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Alport syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "knockout mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclosporin A", "subitem_subject_scheme": "Other"}, {"subitem_subject": "angiotensin converting enzyme inhibitor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tenascin-C", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "アルポート症候群モデルマウスに対する薬物療法の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "アルポート症候群モデルマウスに対する薬物療法の検討"}, {"subitem_title": "アルポート症候群モデルマウスに対する薬物療法の検討", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1061"], "permalink_uri": "http://hdl.handle.net/10191/2651", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "14271", "relation": {}, "relation_version_is_last": true, "title": ["アルポート症候群モデルマウスに対する薬物療法の検討"], "weko_shared_id": null}