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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第119巻第10号

マウス網膜におけるNMDA型受容体チャネルGluRε1サブユニットの分布と機能

http://hdl.handle.net/10191/4461
16ad00cf-9f14-487c-9e61-88ba5e1c803c
名前 / ファイル ライセンス アクション
KJ00004348499.pdf KJ00004348499.pdf (1.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル マウス網膜におけるNMDA型受容体チャネルGluRε1サブユニットの分布と機能
タイトル
言語 en
タイトル マウス網膜におけるNMDA型受容体チャネルGluRε1サブユニットの分布と機能
言語
言語 jpn
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Synaptic Localization and Physiological Function of NMDA Receptor GluRε1 Subunit in the Mouse Retina
著者 葉山, 文恵

× 葉山, 文恵

WEKO 82637

葉山, 文恵

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内容記述タイプ Abstract
内容記述 Glutamate is the main excitatory neurotransmitter in the vertical signal pathway in the vertebrate retina. There are a variety of glutamate receptors (GluRs) in the retina, out of which NMDA receptor is known to regulate synaptic neurotransmission. In order to clarify its function in the retina, I selected GluRε1, one of four NMDA receptor ε subunits, and analyzed the GluRε1 subunit knockout mouse. Immunohistochemistry showed GluRε1, ε2, ζ1 subunit expressions in the outer two-fifth of the inner plexiform layer (IPL) where bipolar cells transfer mostly the OFF signal to amacrine and ganglion cells, suggesting that these subunits were expressed in ganglion and amacrine cells and might participate mainly in the OFF pathways. Physiological functions of the retina were analyzed by electroretinogram (ERG). No significant difference was observed in the amplitude and implicit time of b-wave and amplitude of OPs between wild-type and GluRε1 knockout mice, although there are some reports showing that NMDA receptors are involved in ERG b-wave and oscillatory potentials (OPs). The phenomenon that NMDA currents were reduced but remained in the area where GluRε1 and ε2 were co-localized suggests that GluRε2 subunit might have compensated for the deletion of GluRε1. This is the first study applying ERG in the functional analysis of GluRε1 in retina.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 119, 号 10, p. 626-634, 発行日 2005-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
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