{"_buckets": {"deposit": "2f2bb477-17bd-4c5b-8693-ae8f149fba3e"}, "_deposit": {"id": "12346", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "12346"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00012346"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Synaptic Localization and Physiological Function of NMDA Receptor GluR\u03b51 Subunit in the Mouse Retina"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "634", "bibliographicPageStart": "626", "bibliographicVolumeNumber": "119", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Glutamate is the main excitatory neurotransmitter in the vertical signal pathway in the vertebrate retina. There are a variety of glutamate receptors (GluRs) in the retina, out of which NMDA receptor is known to regulate synaptic neurotransmission. In order to clarify its function in the retina, I selected GluR\u03b51, one of four NMDA receptor \u03b5 subunits, and analyzed the GluR\u03b51 subunit knockout mouse. Immunohistochemistry showed GluR\u03b51, \u03b52, \u03b61 subunit expressions in the outer two-fifth of the inner plexiform layer (IPL) where bipolar cells transfer mostly the OFF signal to amacrine and ganglion cells, suggesting that these subunits were expressed in ganglion and amacrine cells and might participate mainly in the OFF pathways. Physiological functions of the retina were analyzed by electroretinogram (ERG). No significant difference was observed in the amplitude and implicit time of b-wave and amplitude of OPs between wild-type and GluR\u03b51 knockout mice, although there are some reports showing that NMDA receptors are involved in ERG b-wave and oscillatory potentials (OPs). The phenomenon that NMDA currents were reduced but remained in the area where GluR\u03b51 and \u03b52 were co-localized suggests that GluR\u03b52 subunit might have compensated for the deletion of GluR\u03b51. This is the first study applying ERG in the functional analysis of GluR\u03b51 in retina.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u8449\u5c71, \u6587\u6075"}], "nameIdentifiers": [{"nameIdentifier": "82637", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004348499.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "KJ00004348499.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/12346/files/KJ00004348499.pdf"}, "version_id": "06538f62-f9db-4e65-a8a1-ae9e4a876535"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30de\u30a6\u30b9\u7db2\u819c\u306b\u304a\u3051\u308bNMDA\u578b\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30ebGluR\u03b51\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u5206\u5e03\u3068\u6a5f\u80fd", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30de\u30a6\u30b9\u7db2\u819c\u306b\u304a\u3051\u308bNMDA\u578b\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30ebGluR\u03b51\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u5206\u5e03\u3068\u6a5f\u80fd"}, {"subitem_title": "\u30de\u30a6\u30b9\u7db2\u819c\u306b\u304a\u3051\u308bNMDA\u578b\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30ebGluR\u03b51\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u5206\u5e03\u3068\u6a5f\u80fd", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1022"], "permalink_uri": "http://hdl.handle.net/10191/4461", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "12346", "relation": {}, "relation_version_is_last": true, "title": ["\u30de\u30a6\u30b9\u7db2\u819c\u306b\u304a\u3051\u308bNMDA\u578b\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30ebGluR\u03b51\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u306e\u5206\u5e03\u3068\u6a5f\u80fd"], "weko_shared_id": null}