WEKO3
アイテム
ラット悪性脳腫瘍における血管構築,血管透過性および糖輸送担体(GLUT)
http://hdl.handle.net/10191/5273
http://hdl.handle.net/10191/52731ab43efe-3f25-48ed-94f3-4a2d07654f5d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
21_0002.pdf (4.6 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | ラット悪性脳腫瘍における血管構築,血管透過性および糖輸送担体(GLUT) | |||||
| タイトル | ||||||
| タイトル | ラット悪性脳腫瘍における血管構築,血管透過性および糖輸送担体(GLUT) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rat brain tumor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vasculature | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | permeability | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GLUT | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mRNA | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | The Vascular structure, Permeability, and Glucose Transporter in Rat Malignant Brain Tumor | |||||
| 著者 |
倉島, 昭彦
× 倉島, 昭彦 |
|||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 81759 | |||||
| 姓名 | Kurashima, Akihiko | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Glucose is the major substrate for brain tumor energy metabolism. It is widely accepted most tumor cells display increased glucose uptake and glucose metabolism compared to normal cells. Vasculature of brain neoplasm is characterized by abnormal properties important to tumor biology and therapy. This investigation elucidates the association between morphological properties of vasculature, vascularity, permeability, and gene expression of glucose transporter (GLUT) of brain tumor. In the tumor, three regions can be identified on the basis of vascularity and histology: peripheral, intermediate, and central zone. HRP extensively extravasated from abnormally dilated tumor vessels, densely filling the widened extracellular space (ECS) in the intermediate zone. Northern blotting analysis indicated GLUT3 mRNA were up-regulated in each tumor. In situ hybridization revealed that GLUT3 mRNA expression was markedly increased in tumor cells facing necrosis. Increased permeability and widened ECS may provide efficiency in obtaining substrates for energy and cellular proliferation of the tumor. Within the tumor, up-regulation of the GLUT3 gene, like a stress-induced gene, may play an important role in uptake and efficient utilization of glucose in ischemic/hypoxic environments. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 120, 号 5, p. 249-260, 発行日 2006-05 |
|||||
| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
