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In Japan, lung cancer was responsible for 41634 of men and 15086 of women death in 2003, accounting for 18.3% of all cancer death each year and approximately 100,000 death will occur in 2010. Despite chemotherapy with new agents have been shown to improve the survival and quality of life in patients with lung cancer, curable patient is still rare. Molecular target therapy, cellular therapy could be powerful arms to overcome this stagnant situation. 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