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As the development of these MR tools progresses, the leading applications should include the non-invasive monitoring of metabolic-and pharmaco-dynamics within living tissue. In this paper, I introduce two experimental applications demonstrating these types of in vivo MR applications. One is the in vivo monitoring of water environmental changes over anti-edema drug administration in focal ischemic cerebral edema. The other is the magnetic resonance spectroscopy (MRS) monitoring of in vivo pharmaco-dynamics of the polyol pathway in diabatic rats. Based on the directness and non-invasive nature of in vivo MR measurements, we can expect these methods will be widely adopted for clinical use in the near future.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "80477", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Igarashi, Hironaka"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_rights_15": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u672c\u6587\u30c7\u30fc\u30bf\u306f\u5b66\u5354\u4f1a\u306e\u8a31\u8afe\u306b\u57fa\u3065\u304dCiNii\u304b\u3089\u8907\u88fd\u3057\u305f\u3082\u306e\u3067\u3042\u308b"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e94\u5341\u5d50, \u535a\u4e2d"}], "nameIdentifiers": [{"nameIdentifier": "80476", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110006483454.pdf", "filesize": [{"value": "474.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 474200.0, "url": {"label": "110006483454.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/11926/files/110006483454.pdf"}, "version_id": "a23acad0-1b53-44b5-8c67-ac8a39483143"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Magnetic Resonance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Brain", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Metabolism", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pharmacodynamics", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u8133\u4ee3\u8b1d\u30fb\u85ac\u5264\u52d5\u614b\u89e3\u6790\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306eMR", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u8133\u4ee3\u8b1d\u30fb\u85ac\u5264\u52d5\u614b\u89e3\u6790\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306eMR"}, {"subitem_title": "\u8133\u4ee3\u8b1d\u30fb\u85ac\u5264\u52d5\u614b\u89e3\u6790\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306eMR", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1008"], "permalink_uri": "http://hdl.handle.net/10191/20095", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2012-10-19"}, "publish_date": "2012-10-19", "publish_status": "0", "recid": "11926", "relation": {}, "relation_version_is_last": true, "title": ["\u8133\u4ee3\u8b1d\u30fb\u85ac\u5264\u52d5\u614b\u89e3\u6790\u30c4\u30fc\u30eb\u3068\u3057\u3066\u306eMR"], "weko_shared_id": null}