{"_buckets": {"deposit": "79cd5ce6-f93f-4741-a7bc-75929b95c59b"}, "_deposit": {"id": "11558", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "11558"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00011558", "sets": ["456", "1000"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Genetic study for Alzheimer\u0027s disease(Recent Progress in Alzheimer Disease Research)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2007-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "437", "bibliographicPageStart": "432", "bibliographicVolumeNumber": "121", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Alzheimer\u0027s disease (AD) is thought to be a multifactorial disease probably caused by complicated interactions between genetic and environmental factors. A rare form of AD exhibits autosomal dominant inheritance of which the most cases can be caused by mutations in three known genes, amyloid precursor protein, pesenilin 1, and prsenilin 2. To date only the APOE-ε4 allele has been universally recognized as a major risk factor for late-onset AD and also as being associated with lowering of the age at onset. However, about 50 % of AD patients do not carry the APOE-ε4 allele. The identification of an additional genetic risk factor (s) would greatly facilitate our understanding of the neuropathological findings, the clinical manifestations and the varying responses to drugs. To search for susceptibility genes for late-onset AD by means of genome-wide screening, the Japanese Genetic Study Consortium for AD (JGSCAD) was organized in 2000, and blood samples were collected. We found that dynamin binding protein gene (DNMBP) on chromosome 10q was significantly associated with AD lacking the ε4 allele, and DNMBP might play a predominant role in the early stage of AD development.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "78387", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kuwano, Ryozo"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_relation_31": {"attribute_name": "異版である", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://ci.nii.ac.jp/naid/110007146431", "subitem_relation_type_select": "URI"}}]}, "item_7_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "桑野, 良三"}], "nameIdentifiers": [{"nameIdentifier": "78386", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110007146431.pdf", "filesize": [{"value": "565.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 565400.0, "url": {"label": "110007146431.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/11558/files/110007146431.pdf"}, "version_id": "e02b0c75-c44f-4fd9-87c2-ce4081dd7bd8"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Alzheimer\u0027s disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "causative genes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "susceptibility genes", "subitem_subject_scheme": "Other"}, {"subitem_subject": "genome-wide screening", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)"}, {"subitem_title": "1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1000"], "permalink_uri": "http://hdl.handle.net/10191/32761", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-04"}, "publish_date": "2015-08-04", "publish_status": "0", "recid": "11558", "relation": {}, "relation_version_is_last": true, "title": ["1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)"], "weko_shared_id": null}