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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第121巻第8号

1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)

http://hdl.handle.net/10191/32761
http://hdl.handle.net/10191/32761
1d8e716b-ede5-4d85-8108-c965c81f0cd2
名前 / ファイル ライセンス アクション
110007146431.pdf 110007146431.pdf (565.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-04
タイトル
タイトル 1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)
タイトル
言語 en
タイトル 1 アルツハイマー病と遺伝子(シンポジウム 認知症のすべて, 第622回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 Alzheimer's disease
キーワード
主題Scheme Other
主題 causative genes
キーワード
主題Scheme Other
主題 susceptibility genes
キーワード
主題Scheme Other
主題 genome-wide screening
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Genetic study for Alzheimer's disease(Recent Progress in Alzheimer Disease Research)
著者 桑野, 良三

× 桑野, 良三

WEKO 78386

桑野, 良三

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著者別名
識別子 78387
識別子Scheme WEKO
姓名 Kuwano, Ryozo
抄録
内容記述タイプ Abstract
内容記述 Alzheimer's disease (AD) is thought to be a multifactorial disease probably caused by complicated interactions between genetic and environmental factors. A rare form of AD exhibits autosomal dominant inheritance of which the most cases can be caused by mutations in three known genes, amyloid precursor protein, pesenilin 1, and prsenilin 2. To date only the APOE-ε4 allele has been universally recognized as a major risk factor for late-onset AD and also as being associated with lowering of the age at onset. However, about 50 % of AD patients do not carry the APOE-ε4 allele. The identification of an additional genetic risk factor (s) would greatly facilitate our understanding of the neuropathological findings, the clinical manifestations and the varying responses to drugs. To search for susceptibility genes for late-onset AD by means of genome-wide screening, the Japanese Genetic Study Consortium for AD (JGSCAD) was organized in 2000, and blood samples were collected. We found that dynamin binding protein gene (DNMBP) on chromosome 10q was significantly associated with AD lacking the ε4 allele, and DNMBP might play a predominant role in the early stage of AD development.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 121, 号 8, p. 432-437, 発行日 2007-08
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
権利
権利情報 本文データは学協会の許諾に基づきCiNiiから複製したものである
著者版フラグ
値 publisher
異版である
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://ci.nii.ac.jp/naid/110007146431
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