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エピジェネティックス解析法の開発, 診断 (と治療?) への応用
http://hdl.handle.net/10191/28360
http://hdl.handle.net/10191/283606d1b2c7c-53a7-443f-811a-d1cd081be6f4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
123(5)_211-213.pdf (423.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-22 | |||||
| タイトル | ||||||
| タイトル | エピジェネティックス解析法の開発, 診断 (と治療?) への応用 | |||||
| タイトル | ||||||
| タイトル | エピジェネティックス解析法の開発, 診断 (と治療?) への応用 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DNA methylation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | histone acetylation | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Epigenetics, Its Develpoment for the Diagnostic Analyses and for the Treatment | |||||
| 著者 |
藤原, 浩
× 藤原, 浩 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 73294 | |||||
| 姓名 | Fujiwara, Hiroshi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | 'Epigenetics' is an old school of biology; even older than 'genetics'. In this two decades epigenetics has become popular along with the development of analysis technologies. Today epigenetical gene regulation is classified in three, namely, DNA methylation, histone acetylation, and miRNA. The author developed non-isotopic cytosine extension assay to measure whole genome methylation. Through bisulfite PCR and sequence, promoter methylation of CDH1 and several genes were demonstrated in skin cancers. The author developed methylation detection-in situ hybridization to visualize DNA methylation in situ. Combined with mRNA in situ hybridization and protein immunodetection, DNA methylation-mRNA/protein suppression axis was clearly demonstrated. Then pharmacological treatment on primary culture of skin tumor was successfully carried out, and methylation-suppressed gene was re-expressed in situ. Epigenetics can be applied for clinical dignostics any time; for the therapeutic use of epigenetics more breakthrough is warranted. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 123, 号 5, p. 211-213, 発行日 2009-05 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
