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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第123巻第5号

エピジェネティックス解析法の開発, 診断 (と治療?) への応用

http://hdl.handle.net/10191/28360
http://hdl.handle.net/10191/28360
6d1b2c7c-53a7-443f-811a-d1cd081be6f4
名前 / ファイル ライセンス アクション
123(5)_211-213.pdf 123(5)_211-213.pdf (423.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-07-22
タイトル
タイトル エピジェネティックス解析法の開発, 診断 (と治療?) への応用
タイトル
言語 en
タイトル エピジェネティックス解析法の開発, 診断 (と治療?) への応用
言語
言語 jpn
キーワード
主題Scheme Other
主題 DNA methylation
キーワード
主題Scheme Other
主題 histone acetylation
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Epigenetics, Its Develpoment for the Diagnostic Analyses and for the Treatment
著者 藤原, 浩

× 藤原, 浩

WEKO 73293

藤原, 浩

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著者別名
識別子 73294
識別子Scheme WEKO
姓名 Fujiwara, Hiroshi
抄録
内容記述タイプ Abstract
内容記述 'Epigenetics' is an old school of biology; even older than 'genetics'. In this two decades epigenetics has become popular along with the development of analysis technologies. Today epigenetical gene regulation is classified in three, namely, DNA methylation, histone acetylation, and miRNA. The author developed non-isotopic cytosine extension assay to measure whole genome methylation. Through bisulfite PCR and sequence, promoter methylation of CDH1 and several genes were demonstrated in skin cancers. The author developed methylation detection-in situ hybridization to visualize DNA methylation in situ. Combined with mRNA in situ hybridization and protein immunodetection, DNA methylation-mRNA/protein suppression axis was clearly demonstrated. Then pharmacological treatment on primary culture of skin tumor was successfully carried out, and methylation-suppressed gene was re-expressed in situ. Epigenetics can be applied for clinical dignostics any time; for the therapeutic use of epigenetics more breakthrough is warranted.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 123, 号 5, p. 211-213, 発行日 2009-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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