{"_buckets": {"deposit": "336ccbde-2769-4744-83dc-86dda6a08723"}, "_deposit": {"id": "10280", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "10280"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00010280"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Neuroprotective Effects by Simvastatin on Spinal Cord Ischemia/Reperfusion Injury in Rats"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "560", "bibliographicPageStart": "551", "bibliographicVolumeNumber": "124", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u3010\u80cc\u666f\u3011\u4e0b\u884c\u5927\u52d5\u8108, \u80f8\u8179\u90e8\u5927\u52d5\u8108\u306e\u624b\u8853\u306f, \u5927\u52d5\u8108\u906e\u65ad\u306b\u3088\u308b\u4e00\u6642\u7684\u306a\u810a\u9ac4\u865a\u8840\u304c\u907f\u3051\u3089\u308c\u305f\u3081, \u91cd\u7be4\u306a\u5408\u4f75\u75c7\u3067\u3042\u308b\u5bfe\u9ebb\u75fa\u3092\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b. \u5bfe\u9ebb\u75fa\u3092\u9632\u6b62\u3059\u308b\u305f\u3081\u306b, \u4f4e\u4f53\u6e29, \u810a\u9ac4\u30c9\u30ec\u30ca\u30fc\u30b8, \u3084\u865a\u8840\u30d7\u30ec\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u306a\u3069\u306e\u624b\u6bb5\u304c\u3042\u308b\u304c, \u305d\u308c\u3089\u306f\u5fc5\u305a\u3057\u3082\u5145\u5206\u306a\u52b9\u679c\u3092\u3082\u305f\u3089\u305b\u306a\u3044\u3070\u304b\u308a\u304b, \u7169\u96d1\u3067\u4fb5\u8972\u304c\u9ad8\u304f, \u66f4\u306a\u308b\u5408\u4f75\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u3044. \u3088\u3063\u3066, \u4fb5\u8972\u3092\u4f34\u308f\u306a\u3044\u85ac\u7269\u7642\u6cd5\u306b\u3088\u308b\u810a\u9ac4\u4fdd\u8b77\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u308b. \u30b9\u30bf\u30c1\u30f3\u306f\u9ad8\u8102\u8840\u75c7\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u4f7f\u7528\u3055\u308c\u308b\u4e00\u822c\u7684\u3067\u4e14\u3064\u5b89\u5168\u6027\u306e\u78ba\u6b63\u3055\u308c\u305f\u85ac\u5264\u3067\u3042\u308b. \u8fd1\u5e74, \u30b9\u30bf\u30c1\u30f3\u306e\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u306b\u6ce8\u76ee\u3055\u308c, \u8133\u865a\u8840\u518d\u704c\u6d41\u306b\u304a\u3044\u3066\u306f\u8abf\u3079\u3089\u308c\u3066\u304d\u305f\u304c, \u810a\u9ac4\u865a\u8840\u3067\u8a66\u3055\u308c\u305f\u5831\u544a\u306f\u306a\u304b\u3063\u305f. \u305d\u3053\u3067, \u672c\u7814\u7a76\u306b\u304a\u3044\u3066, \u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u304c\u810a\u9ac4\u865a\u8840\u518d\u704c\u6d41\u306b\u4fdd\u8b77\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u304b\u30e9\u30c3\u30c8\u810a\u9ac4\u865a\u8840\u30e2\u30c7\u30eb\u3067\u8a55\u4fa1\u3092\u884c\u306a\u3063\u305f. \u3010\u6750\u6599\u3068\u65b9\u6cd5\u3011\u96c4\u6027SD\u30e9\u30c3\u30c818\u5339 (380-420g) \u3092\u7121\u4f5c\u70ba\u306b Simvastatin 10mg/kg/day (Sim\u7fa4), Vehicle (V\u7fa4), Sham (Sham\u7fa4), \u306e3\u7fa4 (\u5404 n =6) \u306b\u632f\u308a\u5206\u3051\u305f. 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\u3053\u306e\u3068\u304d\u5c3e\u52d5\u8108\u5727\u306e\u8108\u5727\u304c\u7121\u304f\u306a\u308a10mmHg\u4ee5\u4e0b\u306b\u306a\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u810a\u9ac4\u865a\u8840\u3068\u3057\u305f (\u865a\u8840\u6642\u9593\u306f12\u5206). \u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u306e\u810a\u9ac4\u865a\u8840\u518d\u704c\u6d41\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u306f, \u4e0b\u80a2\u904b\u52d5\u80fd\u3068\u7d44\u7e54\u5b66\u7684\u8a55\u4fa1\u3067\u884c\u306a\u3063\u305f. \u4e0b\u80a2\u904b\u52d5\u80fd\u306b\u306f Motor deficit index (MDI) \u3092\u7528\u3044\u3066, \u518d\u704c\u6d41\u5f8c6-48\u6642\u9593\u5f8c\u306b\u8a55\u4fa1\u3057\u305f. \u307e\u305f, 48\u6642\u9593\u5f8c\u306e\u8a55\u4fa1\u7d42\u4e86\u5f8c, \u8170\u81a8\u5927\u90e8\u306e\u30d1\u30e9\u30d5\u30a3\u30f3\u5305\u57cb\u5207\u7247\u3092\u4f5c\u6210\u3057Nissl\u53c8\u306f\u3068HE\u67d3\u8272\u3092\u884c\u306a\u3063\u305f. \u7d44\u7e54\u5b66\u7684\u8a55\u4fa1\u306b\u306f\u7070\u767d\u8cea\u306e\u6b63\u5e38\u795e\u7d4c\u7d30\u80de\u6570\u3068\u767d\u8cea\u306e\u7a7a\u80de\u7387\u3092\u89b3\u5bdf\u3057\u305f. \u3010\u7d50\u679c\u3011\u518d\u704c\u6d41\u5f8c24, 48\u6642\u9593\u5f8c\u306eSim\u7fa4\u306eMDI\u306fV\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u306b\u4e0b\u80a2\u306e\u56de\u5fa9\u3092\u793a\u3057\u305f(P \u003c0.05). \u518d\u704c\u6d4148\u6642\u9593\u5f8c, \u810a\u9ac4\u524d\u89d2\u306e\u6b63\u5e38\u795e\u7d4c\u7d30\u80de\u6570\u306f, Sim\u7fa4\u3067\u306fV\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u306b\u591a\u304b\u3063\u305f(P \u003c0.05). \u307e\u305f, \u767d\u8cea\u306e\u7a7a\u80de\u7387\u306f, Sim\u7fa4\u3068V\u7fa4\u3092\u6bd4\u8f03\u3059\u308b\u3068\u2164\u7fa4\u306f\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f (P \u003c0.05). \u3010\u7d50\u8ad6\u301112\u5206\u9593\u306e\u30e9\u30c3\u30c8\u810a\u9ac4\u865a\u8840\u30e2\u30c7\u30eb\u3067, 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