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Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10)
http://hdl.handle.net/10191/33163
http://hdl.handle.net/10191/33163b3083ca6-cf0a-461c-b296-55c570a61410
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44(2)_79-86.pdf (1.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-27 | |||||
| タイトル | ||||||
| タイトル | Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10) | |||||
| タイトル | ||||||
| タイトル | Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cisplatin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | multidrug resistance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | growth factors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ovarian cancer cell line | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Kamishima, Tomoko
× Kamishima, Tomoko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cis-diamminedichloroplatinum (II) (CDDP) resistant-human ovarian cancer cell line (TYK-R10) was examined for its drug resistance to other anti-cancer drugs, and growth response to various growth factors, compared with the parental cell line (TYK-nu). TYK-R10 was established by a gradual increase in the concentrations of CDDP compared with the parental line. TYK-R10 showed about a ten-fold resistance, with 1×10^<-5> M CDDP of IC_<50>, which represents the concentration of an anti-cancer drug to produce a 50% inhibition of cell growth. TYK-R10 revealed a cross resistance to various anti-cancer drugs including carboplatin (CBDCA), vincristin (VCR) and adriamycin (ADR). However, no significant alternations in topoisomerase II, glutathione-S-transferase levels or glutathione concentrations were detected. In addition, P-glycoprotein (P-gp) was not expressed on the cell surface of TYK-R10 and verapamil had no reverse effect on resistance to CDDP, CBDCA, VCR and ADR. Surface marker analysis using epidermal growth factor receptor antibody disclosed a high positivity in TYK-R10, compared with TYK-nu, and consequently epidermal growth factor activated the growth of TYK-R10. Transforming growth factor α had no effect on the growth of TYK-R10, whereas it promoted the growth of TYK-nu. In contrast, transforming growth factor β promoted the growth of TYK-nu, whereas it inhibited the growth of TYK-R10. These results indicate that the mechanism of multidrug resistance of TYK-R10 is not mediated through P-gp, and that altered responsibility for some growth factor in TYK-R10 is closely associated with the acquisition of CDDP resistance. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 2, p. 79-86, 発行日 1996-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Kamishima, Tomoko, 1996, Characteristic Cross Resistance to Anti-Cancer Drugs and Different Responses for Various Growth Factors in Cisplatin Resistant-Human Ovarian Cancer Cell Line (TYK-R10): Niigata University School of Medicine, 79–86 p.
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