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A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)
http://hdl.handle.net/10191/1850
http://hdl.handle.net/10191/185004d929da-38f2-4639-926e-57470054ef86
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267697.pdf (2.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS) | |||||
| タイトル | ||||||
| タイトル | A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methicillin-resistant Staphylococcus aureus (MRSA) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | multiple superantigenic toxin (MST) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | toxic shock syndrome (TSS) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | risk factor | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
TAKIZAWA, Yoko
× TAKIZAWA, Yoko× SHIMIZU, Takao× IWAYA, Akira× HATAKEYAMA, Katsuyoshi× TANEIKE, Ikue× NAKAGAWA, Saori× NYUZUKI, Satoru× GONDAIRA, Fumio× TSUKADA, Hiroki× GEJYO, Fumitake× YAMAMOTO, Tatsuo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Methicillin-resistant Staphylococcus aureus (MRSA), an important cause of nosocomial infections, produces a number of superantigenic toxins such as toxic shock syndrome toxin (TSST)-1 and staphylococcal enterotoxin (SE) C in many cases. However, toxic shock syndrome (TSS) only rarely occurs in MRSA infections. In this study, we isolated MRSA strains from the stool and sputum of a patient with TSS and characterized the molecular nature of the TSS-associated MRSA strains. The two MRSA strains were indistinguishable from each other, as demonstrated by pulsed-field gel electrophoresis. The coagulase type was type 2. The two MRSA strains manifested a multiple superantigenic toxin (MST) pattern of TSST-1, SEA, SEC, SEG, SEH, SEI, and SET in the PCR assay, unlike the previously characterized MRSA strains that lacked (e. g.) SEA. When human peripheral blood mononuclear cells were stimulated with superantigenic toxins, a combination of TSST-1, SEA, and SEC induced much higher levels of cytokine production than did the individual toxin or combination of (e. g.) TSST-1 and SEC. The data suggest that the MST pattern of MRSA could be a risk factor in the development of TSS. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 51, 号 4, p. 141-147, 発行日 2003-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
