{"created":"2021-03-01T06:10:09.435983+00:00","id":6260,"links":{},"metadata":{"_buckets":{"deposit":"604d78ef-f894-447d-9e24-65104df1b2fc"},"_deposit":{"id":"6260","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6260"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006260","sets":["453:456","471:537:568:590"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"147","bibliographicPageStart":"141","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Methicillin-resistant Staphylococcus aureus (MRSA), an important cause of nosocomial infections, produces a number of superantigenic toxins such as toxic shock syndrome toxin (TSST)-1 and staphylococcal enterotoxin (SE) C in many cases. However, toxic shock syndrome (TSS) only rarely occurs in MRSA infections. In this study, we isolated MRSA strains from the stool and sputum of a patient with TSS and characterized the molecular nature of the TSS-associated MRSA strains. The two MRSA strains were indistinguishable from each other, as demonstrated by pulsed-field gel electrophoresis. The coagulase type was type 2. The two MRSA strains manifested a multiple superantigenic toxin (MST) pattern of TSST-1, SEA, SEC, SEG, SEH, SEI, and SET in the PCR assay, unlike the previously characterized MRSA strains that lacked (e. g.) SEA. When human peripheral blood mononuclear cells were stimulated with superantigenic toxins, a combination of TSST-1, SEA, and SEC induced much higher levels of cytokine production than did the individual toxin or combination of (e. g.) TSST-1 and SEC. The data suggest that the MST pattern of MRSA could be a risk factor in the development of TSS.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAKIZAWA, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"51977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMIZU, Takao"}],"nameIdentifiers":[{"nameIdentifier":"51978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IWAYA, Akira"}],"nameIdentifiers":[{"nameIdentifier":"51979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HATAKEYAMA, Katsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"51980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANEIKE, Ikue"}],"nameIdentifiers":[{"nameIdentifier":"51981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAKAGAWA, Saori"}],"nameIdentifiers":[{"nameIdentifier":"51982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NYUZUKI, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"51983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GONDAIRA, Fumio"}],"nameIdentifiers":[{"nameIdentifier":"51984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TSUKADA, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"51985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GEJYO, Fumitake"}],"nameIdentifiers":[{"nameIdentifier":"51986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YAMAMOTO, Tatsuo"}],"nameIdentifiers":[{"nameIdentifier":"51987","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00004267697.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004267697.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6260/files/KJ00004267697.pdf"},"version_id":"dcbcce75-ac55-4328-b4ca-65e6f061ced7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"methicillin-resistant Staphylococcus aureus (MRSA)","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple superantigenic toxin (MST)","subitem_subject_scheme":"Other"},{"subitem_subject":"toxic shock syndrome (TSS)","subitem_subject_scheme":"Other"},{"subitem_subject":"risk factor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)"},{"subitem_title":"A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","590"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6260","relation_version_is_last":true,"title":["A Multiple Superantigenic Toxin Pattern of Methicillin-resistant Staphylococcus aureus (MRSA) as a Risk Factor in the Development of Toxic Shock Syndrome (TSS)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:37.138295+00:00"}