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インターフェロンによる肝発癌予防
http://hdl.handle.net/10191/28130
http://hdl.handle.net/10191/28130272b82f9-8a18-4601-af0c-55c3907573a6
名前 / ファイル | ライセンス | アクション |
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122(11)_611-618.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-07-18 | |||||
タイトル | ||||||
タイトル | インターフェロンによる肝発癌予防 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | インターフェロンによる肝発癌予防 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hepatocellular Carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interferon-β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transgenic mouse | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-proliferative effect | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Prevention of Hepatocellular Carcinoma by Interferon | |||||
著者 |
大越, 章吾
× 大越, 章吾 |
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著者別名 | ||||||
識別子 | 74606 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ohkoshi, Shogo | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hepatocellular carcinoma (HCC) is one of the major causes of cancer- death in Japan. Majority of HCC patients are due to chronic hepatitis B or C infection. Interferon is a principal anti-viral agent for chronic viral hepatitis which has variety of biological functions. We particularly focused on the anti-proliferative function of interferon and sought to determine whether the temporal administration of IFN-β prevents hepatocarcinogenesis in a mouse model where HCC develops without necroinflammation. Hepatocarcinogenic mice that are transgenic for the hepatitis B virus X gene (HBx-Tg) were treated with IFN-β or saline (control) for 3 months, from 3 to 6 months of age, and the incidence of HCC was determined at 18 months of age. The incidence of HCC was significantly lower in the IFN-β-treated mice than the controls (0 vs 50%, P<0.01). Inhibition of DNA synthesis in hepatocytes by IFN-β was observed in the liver of HBx-Tg, without any significant induction of apoptosis. Thus, temporal administration of IFN-β has a significant preventive effect on the occurrence of HCC in a mouse model where HCC devel-ops without inflammation. The mechanisms are the inhibition of DNA synthesis and cell cycle progression of hepatocytes. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 122, 号 11, p. 611-618, 発行日 2008-11 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |