{"created":"2021-03-01T06:15:07.154906+00:00","id":10947,"links":{},"metadata":{"_buckets":{"deposit":"ad797e50-0a81-4af4-be30-5806668033ae"},"_deposit":{"id":"10947","owners":[],"pid":{"revision_id":0,"type":"depid","value":"10947"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00010947","sets":["453:456","471:537:538:985"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Prevention of Hepatocellular Carcinoma by Interferon"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"618","bibliographicPageStart":"611","bibliographicVolumeNumber":"122","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatocellular carcinoma (HCC) is one of the major causes of cancer- death in Japan. Majority of HCC patients are due to chronic hepatitis B or C infection. Interferon is a principal anti-viral agent for chronic viral hepatitis which has variety of biological functions. We particularly focused on the anti-proliferative function of interferon and sought to determine whether the temporal administration of IFN-β prevents hepatocarcinogenesis in a mouse model where HCC develops without necroinflammation. Hepatocarcinogenic mice that are transgenic for the hepatitis B virus X gene (HBx-Tg) were treated with IFN-β or saline (control) for 3 months, from 3 to 6 months of age, and the incidence of HCC was determined at 18 months of age. The incidence of HCC was significantly lower in the IFN-β-treated mice than the controls (0 vs 50%, P<0.01). Inhibition of DNA synthesis in hepatocytes by IFN-β was observed in the liver of HBx-Tg, without any significant induction of apoptosis. Thus, temporal administration of IFN-β has a significant preventive effect on the occurrence of HCC in a mouse model where HCC devel-ops without inflammation. The mechanisms are the inhibition of DNA synthesis and cell cycle progression of hepatocytes.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"74606","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohkoshi, Shogo"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大越, 章吾"}],"nameIdentifiers":[{"nameIdentifier":"74605","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"122(11)_611-618.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"122(11)_611-618.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/10947/files/122(11)_611-618.pdf"},"version_id":"7ac003f8-861f-4b68-a6fc-22dff3aa28a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepatocellular Carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"interferon-β","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-proliferative effect","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"インターフェロンによる肝発癌予防","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インターフェロンによる肝発癌予防"},{"subitem_title":"インターフェロンによる肝発癌予防","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","985"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-18"},"publish_date":"2014-07-18","publish_status":"0","recid":"10947","relation_version_is_last":true,"title":["インターフェロンによる肝発癌予防"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:44:29.427007+00:00"}