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胸腺外分化T細胞の性差とアンドロゲンによる制御
http://hdl.handle.net/10191/38108
http://hdl.handle.net/10191/38108247f965e-af9a-4506-b230-c42ca9227241
名前 / ファイル | ライセンス | アクション |
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108(3)_200-211.pdf (2.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-08 | |||||
タイトル | ||||||
タイトル | 胸腺外分化T細胞の性差とアンドロゲンによる制御 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 胸腺外分化T細胞の性差とアンドロゲンによる制御 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | extrathymic T cell differentiation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intermediate TCR cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | androgen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sex difference | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | flow cytometry | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胸腺外分化T細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | intermediate TCR 細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | アンドロゲン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 性差 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | フローサイトメトリー | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Sex Difference of Extrathymic T-Cells and Its Regulation by Androgen | |||||
著者 |
木村, 元彦
× 木村, 元彦 |
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著者別名 | ||||||
識別子 | 121152 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kimura, Motohiko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Male predominance of malignant disease and female predominance of autoimmune disease are widely known in humans. To elucidate one of the underlying mechanisms, we examined whether sex differences exist at the level of extrathymic T cells in various organs of mice under physiological conditions. Effects of orchiectomy or testosterone administration were also examined. Extrathymic T cells expressing CD3 of intermediate intensity (i. e., intermediate TCR cells) and a high level of IL-2 receptor β-chain (IL-2Rβ), and thymusderived T cells expressing of TCR of bright intensity (i. e., bright TCR cells) and lacking IL-2Rβ, were identified by immunofluorescent tests. Of each three strain tested, it was demonstrated that intermediate TCR cells were much more predominant in the liver and some other organs in female mice than in male mice. In the liver of orchiectomied mice, the number of mononuclear cells increasod and intermediate TCR cells became predominant as if the mice were female. Testosterone replacement canceled the immunological effect of orchiectomy. Considering the fact that extrathymic T cells comprise a considerable proportion of self-reactive forbidden clones and possess cytotoxic activity aganinst syngenic tumor cells, the present results might suggest a possible relationship between physiologically low levels of extrathymic T cells and the male predominance of malignancy. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 3, p. 200-211, 発行日 1994-03 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |