{"created":"2021-03-01T06:24:20.718184+00:00","id":19484,"links":{},"metadata":{"_buckets":{"deposit":"abc04c5b-bf22-478e-9640-1a42f3535317"},"_deposit":{"id":"19484","owners":[],"pid":{"revision_id":0,"type":"depid","value":"19484"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00019484","sets":["453:456","471:537:538:1152"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Sex Difference of Extrathymic T-Cells and Its Regulation by Androgen"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"211","bibliographicPageStart":"200","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Male predominance of malignant disease and female predominance of autoimmune disease are widely known in humans. To elucidate one of the underlying mechanisms, we examined whether sex differences exist at the level of extrathymic T cells in various organs of mice under physiological conditions. Effects of orchiectomy or testosterone administration were also examined. Extrathymic T cells expressing CD3 of intermediate intensity (i. e., intermediate TCR cells) and a high level of IL-2 receptor β-chain (IL-2Rβ), and thymusderived T cells expressing of TCR of bright intensity (i. e., bright TCR cells) and lacking IL-2Rβ, were identified by immunofluorescent tests. Of each three strain tested, it was demonstrated that intermediate TCR cells were much more predominant in the liver and some other organs in female mice than in male mice. In the liver of orchiectomied mice, the number of mononuclear cells increasod and intermediate TCR cells became predominant as if the mice were female. Testosterone replacement canceled the immunological effect of orchiectomy. Considering the fact that extrathymic T cells comprise a considerable proportion of self-reactive forbidden clones and possess cytotoxic activity aganinst syngenic tumor cells, the present results might suggest a possible relationship between physiologically low levels of extrathymic T cells and the male predominance of malignancy.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"121152","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura, Motohiko"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 元彦"}],"nameIdentifiers":[{"nameIdentifier":"121151","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-08"}],"displaytype":"detail","filename":"108(3)_200-211.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"108(3)_200-211.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/19484/files/108(3)_200-211.pdf"},"version_id":"1927a8a6-7c53-4fb5-bc09-49c36c136e6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"extrathymic T cell differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"intermediate TCR cells","subitem_subject_scheme":"Other"},{"subitem_subject":"androgen","subitem_subject_scheme":"Other"},{"subitem_subject":"sex difference","subitem_subject_scheme":"Other"},{"subitem_subject":"flow cytometry","subitem_subject_scheme":"Other"},{"subitem_subject":"胸腺外分化T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"intermediate TCR 細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"アンドロゲン","subitem_subject_scheme":"Other"},{"subitem_subject":"性差","subitem_subject_scheme":"Other"},{"subitem_subject":"フローサイトメトリー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胸腺外分化T細胞の性差とアンドロゲンによる制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胸腺外分化T細胞の性差とアンドロゲンによる制御"},{"subitem_title":"胸腺外分化T細胞の性差とアンドロゲンによる制御","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1152"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-08"},"publish_date":"2016-02-08","publish_status":"0","recid":"19484","relation_version_is_last":true,"title":["胸腺外分化T細胞の性差とアンドロゲンによる制御"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:50:23.373577+00:00"}