{"created":"2021-03-01T06:14:06.315439+00:00","id":9996,"links":{},"metadata":{"_buckets":{"deposit":"bf658de6-ffc2-40d5-b0e8-00f98f5cb725"},"_deposit":{"id":"9996","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9996"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009996","sets":["453:456","471:537:538:955"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Bcl11b Modulates β-catenin Expression and its effect on Mouse Thymocyte Differentiation"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"268","bibliographicPageStart":"259","bibliographicVolumeNumber":"125","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胸腺細胞の分化・成熟にβカテニンおよびBcl11bは重要な働きをする. βカテニンはWntシグナル系の下流に位置し, 刺激後に核内に移行し, Tcf/Lefのコアクチべーターとして, 様々な標的遺伝子の発現調節を行う. 一方, Bcl11bはzinc finger ドメインをもつ転写因子であり, ハプロ不全な癌抑制遺伝子である. 両者とも胸腺T細胞の分化に影響するが, その関連性は明らかでない. そこで, APC^<min/+>マウス, Bcl11b^<KO/+>マウス, Bcl11b^<S826G>変異マウスを用い, 細胞分化の進行度と各々の分化段階にある胸腺細胞内のβカテニン発現量を測定した. APC^<min/+>マウスでβカテニンの上昇が観察され, これは生理的な発現調節に従うものであった. また, 胸腺細胞の分化, 成熟を促進させることが分かった. 一方, Bcl11b発現の低下しているマウスでもβカテニンの上昇が確認されたが, APC^<min/+>マウスとではβカテニンの発現レベルが細胞種で異なることが分かった. すなわち, 生理的な発現とは異なる特異な発現誘導を示した. そこで, 両者の影響を同時に受けるBcl11b^<KO/+>; APC^<min/+>マウスを作製し検討した結果, βカテニンの発現上昇はみられたが, APC^<min/+>マウスでみられた分化の促進は観察されなかった. これらの結果は, Bcl11bがβカテニン遺伝子を含む遺伝子発現に影響すること, その総合的な発現結果が胸腺細胞分化に影響すること, を示唆する.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"68933","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Morita, Shinichi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森田, 慎一"}],"nameIdentifiers":[{"nameIdentifier":"68932","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"125(5)_259-268.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"125(5)_259-268.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9996/files/125(5)_259-268.pdf"},"version_id":"eb6f94d0-4bea-49c5-a499-069ea4811b72"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bcl11b転写因子","subitem_subject_scheme":"Other"},{"subitem_subject":"βカテニン","subitem_subject_scheme":"Other"},{"subitem_subject":"APC^<min/+>マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"胸腺","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"βカテニンの胸腺細胞分化への役割とBcl11bによるその修飾","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"βカテニンの胸腺細胞分化への役割とBcl11bによるその修飾"},{"subitem_title":"βカテニンの胸腺細胞分化への役割とBcl11bによるその修飾","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","955"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-29"},"publish_date":"2014-07-29","publish_status":"0","recid":"9996","relation_version_is_last":true,"title":["βカテニンの胸腺細胞分化への役割とBcl11bによるその修飾"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:51.223652+00:00"}