{"created":"2021-03-01T06:14:00.184797+00:00","id":9899,"links":{},"metadata":{"_buckets":{"deposit":"6abb34b7-91f1-4774-af8d-50ccc39fc8bb"},"_deposit":{"id":"9899","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9899"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009899","sets":["453:456","471:537:538:950"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mechanism of Leukemogenesis by Human T-cell Leukemia Virus Type 1 (HTLV-1)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"531","bibliographicPageStart":"526","bibliographicVolumeNumber":"125","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒトT細胞白血病ウイルス1型 (HTLV-1) は成人T細胞白血病 (ATL) の原因ウイルスである. ATLは, HTLV-1感染者のうち約5%が, 平均60年の潜伏感染の後に発症する極めて悪性の白血病である. HTLV-1と近縁のヒトレトロウイルスとしてHTLV-2が知られている. HTLV-2はHTLV-1と同様に, 感染T細胞の増殖を促進し不死化させる. しかしながら, HTLV-1と異なりHTLV-2感染は白血病を起こすことはない. 我々はこれらのウイルスのもつトランスフォーミング蛋白, HTLV-1 Tax1 と HTLV-2 Tax2の機能の違いが, 病原性の有無を規定しているとの仮説をたてた. Tax1はマウスT細胞株CTLL-2をIL－2依存性から非依存性へとトランスフォームするが, Tax2においてはその活性が顕著に低下する. この違いはTax1の2つの特異的な機能, PDZドメイン蛍白の不活化とNF-_κB2の活性化に起因することがわかった. またTax2はNFATを活性化する特異的な作用をもち, NFATを介したIL-2の分泌により感染T細胞を増殖させていることが明らかとなった. これらの増殖様式の違いは, HTLV-1感染細胞に遺伝子変異を蓄積させるように働き, その結果としてATLの発症が促される可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"68307","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Higuchi, Masaya"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 雅也"}],"nameIdentifiers":[{"nameIdentifier":"68306","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"125(10)_526-531.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"125(10)_526-531.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9899/files/125(10)_526-531.pdf"},"version_id":"e86e55dd-e8d7-4f8d-9b16-383279782d88"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"成人T細胞白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"ATL","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒトT細胞白血病ウイルス1型 (HTLV-1) による白血病発症機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトT細胞白血病ウイルス1型 (HTLV-1) による白血病発症機構"},{"subitem_title":"ヒトT細胞白血病ウイルス1型 (HTLV-1) による白血病発症機構","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","950"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-29"},"publish_date":"2014-07-29","publish_status":"0","recid":"9899","relation_version_is_last":true,"title":["ヒトT細胞白血病ウイルス1型 (HTLV-1) による白血病発症機構"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:49.232266+00:00"}