{"created":"2021-03-01T06:14:00.184797+00:00","id":9899,"links":{},"metadata":{"_buckets":{"deposit":"6abb34b7-91f1-4774-af8d-50ccc39fc8bb"},"_deposit":{"id":"9899","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9899"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009899"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"Mechanism of Leukemogenesis by Human T-cell Leukemia Virus Type 1 (HTLV-1)"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"531","bibliographicPageStart":"526","bibliographicVolumeNumber":"125","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b (HTLV-1) \u306f\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5 (ATL) \u306e\u539f\u56e0\u30a6\u30a4\u30eb\u30b9\u3067\u3042\u308b. ATL\u306f, HTLV-1\u611f\u67d3\u8005\u306e\u3046\u3061\u7d045%\u304c, \u5e73\u574760\u5e74\u306e\u6f5c\u4f0f\u611f\u67d3\u306e\u5f8c\u306b\u767a\u75c7\u3059\u308b\u6975\u3081\u3066\u60aa\u6027\u306e\u767d\u8840\u75c5\u3067\u3042\u308b. HTLV-1\u3068\u8fd1\u7e01\u306e\u30d2\u30c8\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u3068\u3057\u3066HTLV-2\u304c\u77e5\u3089\u308c\u3066\u3044\u308b. HTLV-2\u306fHTLV-1\u3068\u540c\u69d8\u306b, \u611f\u67d3T\u7d30\u80de\u306e\u5897\u6b96\u3092\u4fc3\u9032\u3057\u4e0d\u6b7b\u5316\u3055\u305b\u308b. \u3057\u304b\u3057\u306a\u304c\u3089, HTLV-1\u3068\u7570\u306a\u308aHTLV-2\u611f\u67d3\u306f\u767d\u8840\u75c5\u3092\u8d77\u3053\u3059\u3053\u3068\u306f\u306a\u3044. \u6211\u3005\u306f\u3053\u308c\u3089\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u3082\u3064\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30df\u30f3\u30b0\u86cb\u767d, HTLV-1 Tax1 \u3068 HTLV-2 Tax2\u306e\u6a5f\u80fd\u306e\u9055\u3044\u304c, \u75c5\u539f\u6027\u306e\u6709\u7121\u3092\u898f\u5b9a\u3057\u3066\u3044\u308b\u3068\u306e\u4eee\u8aac\u3092\u305f\u3066\u305f. Tax1\u306f\u30de\u30a6\u30b9T\u7d30\u80de\u682aCTLL-2\u3092IL\uff0d2\u4f9d\u5b58\u6027\u304b\u3089\u975e\u4f9d\u5b58\u6027\u3078\u3068\u30c8\u30e9\u30f3\u30b9\u30d5\u30a9\u30fc\u30e0\u3059\u308b\u304c, Tax2\u306b\u304a\u3044\u3066\u306f\u305d\u306e\u6d3b\u6027\u304c\u9855\u8457\u306b\u4f4e\u4e0b\u3059\u308b. \u3053\u306e\u9055\u3044\u306fTax1\u306e2\u3064\u306e\u7279\u7570\u7684\u306a\u6a5f\u80fd, PDZ\u30c9\u30e1\u30a4\u30f3\u86cd\u767d\u306e\u4e0d\u6d3b\u5316\u3068NF-_\u03baB2\u306e\u6d3b\u6027\u5316\u306b\u8d77\u56e0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f. \u307e\u305fTax2\u306fNFAT\u3092\u6d3b\u6027\u5316\u3059\u308b\u7279\u7570\u7684\u306a\u4f5c\u7528\u3092\u3082\u3061, NFAT\u3092\u4ecb\u3057\u305fIL-2\u306e\u5206\u6ccc\u306b\u3088\u308a\u611f\u67d3T\u7d30\u80de\u3092\u5897\u6b96\u3055\u305b\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f. \u3053\u308c\u3089\u306e\u5897\u6b96\u69d8\u5f0f\u306e\u9055\u3044\u306f, HTLV-1\u611f\u67d3\u7d30\u80de\u306b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u84c4\u7a4d\u3055\u305b\u308b\u3088\u3046\u306b\u50cd\u304d, \u305d\u306e\u7d50\u679c\u3068\u3057\u3066ATL\u306e\u767a\u75c7\u304c\u4fc3\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"68307","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Higuchi, Masaya"}]}]},"item_7_publisher_7":{"attribute_name":"\u51fa\u7248\u8005","attribute_value_mlt":[{"subitem_publisher":"\u65b0\u6f5f\u533b\u5b66\u4f1a"}]},"item_7_select_19":{"attribute_name":"\u8457\u8005\u7248\u30d5\u30e9\u30b0","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"\u8457\u8005","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"\u6a0b\u53e3, \u96c5\u4e5f"}],"nameIdentifiers":[{"nameIdentifier":"68306","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"125(10)_526-531.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"125(10)_526-531.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9899/files/125(10)_526-531.pdf"},"version_id":"e86e55dd-e8d7-4f8d-9b16-383279782d88"}]},"item_keyword":{"attribute_name":"\u30ad\u30fc\u30ef\u30fc\u30c9","attribute_value_mlt":[{"subitem_subject":"\u6210\u4ebaT\u7d30\u80de\u767d\u8840\u75c5","subitem_subject_scheme":"Other"},{"subitem_subject":"ATL","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"\u8a00\u8a9e","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"\u8cc7\u6e90\u30bf\u30a4\u30d7","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b (HTLV-1) \u306b\u3088\u308b\u767d\u8840\u75c5\u767a\u75c7\u6a5f\u69cb","item_titles":{"attribute_name":"\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_title":"\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b (HTLV-1) \u306b\u3088\u308b\u767d\u8840\u75c5\u767a\u75c7\u6a5f\u69cb"},{"subitem_title":"\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b (HTLV-1) \u306b\u3088\u308b\u767d\u8840\u75c5\u767a\u75c7\u6a5f\u69cb","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/950"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2014-07-29"},"publish_date":"2014-07-29","publish_status":"0","recid":"9899","relation_version_is_last":true,"title":["\u30d2\u30c8T\u7d30\u80de\u767d\u8840\u75c5\u30a6\u30a4\u30eb\u30b91\u578b (HTLV-1) \u306b\u3088\u308b\u767d\u8840\u75c5\u767a\u75c7\u6a5f\u69cb"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T18:09:42.864065+00:00"}