@article{oai:niigata-u.repo.nii.ac.jp:00009707,
 author = {佐藤, 洋輔 and 福多, 真史 and 大石, 誠 and 藤井, 幸彦},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {In this study, we applied near-infrared spectroscopy (NIRS) recordings during cortical stimulation to a patient with temporal lobe epilepsy. Our aim was to determine hemodynamic changes of the cortex during direct cortical electrical stimulation, focusing not only on the stimulated region but also on different regions distant from the stimulated site. An 18-year-old man presented with refractory complex partial seizures. To evaluate the epileptic focus, subdural and depth electrodes were implanted in the left temporal lobe. Using NIRS, changes in blood concentrations of oxyhemoglobin (HbO_2) and deoxyhemoglobin (HbR) during cortical stimulation of the left language areas were measured in each cerebral hemisphere covering the language areas. NIRS revealed that the 50 Hz stimulation elicited significant increases in both HbO_2 and HbR at the stimulation site. Furthermore, in the 50 Hz stimulation of the left superior temporal gyrus, the increases in HbO_2 and HbR were observed not only at the stimulation site but also concurrently at the left inferior frontal gyrus. This suggests the existence of functional connectivity in the language system. The present Study is the first to demonstrate that NIRS study during cortical stimulation allows a novel analysis of cerebral connectivity.},
 pages = {265--268},
 title = {直接脳表電気刺激下NIRSによる言語機能神経ネットワーク解析},
 volume = {126},
 year = {2012}
}