{"created":"2021-03-01T06:13:46.783216+00:00","id":9688,"links":{},"metadata":{"_buckets":{"deposit":"5a8a7f8d-35b3-46e3-941a-046e12d30ba9"},"_deposit":{"id":"9688","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9688"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009688","sets":["453:456","471:537:538:942"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Treatment of Psoriasis with Biologics (Biologics for the Treatment of Inflammatory Disease)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"300","bibliographicPageStart":"293","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本邦において, 2010年1月にTNF-_α阻害剤のインフリキシマブ (以下IFX) とアダリムマブ (以下ADM) が乾癬に対する保険適応を取得した. 当科でこの生物学的製剤を授与した乾癬の2症例を報告した. 症例1は48歳, 男性の膿疱性乾癬. エトレチナート, シクロスポリンは有効であったが, 遅れて発症した慢性糸球体腎炎のため継続できなくなった. プレドニゾロン (PSL) の内服, ステロイド外用, 紫外線療法の併用を行ったが, PSLを減量するたびに膿疱の再燃を繰り返しIFXの投与に至った. 投与8日目に膿疱の新生はなくなり, 18週目に Psoriasis Area and Severity Index (PASI) 71%改善を達成した. PSLは, IFX開始時の50mg/日から漸減し14週目には10mg/日にすることが可能だった. 症例2は40歳, 女性の関節症性乾癬. NSAIDsで改善しない多関節痛のため日常生活に支障をきたす状態だった. ADM投与翌日より関節痛の著明な軽減を認め, それ以降NSAIDsは不要となった. 12週目にPASI80%改善を達成した. 関節症性乾癬に対しては関節の障害や破壊が進行する前の, 発症早期の段階で投与するのはもちろんのこと, 他の病型の中等症から重症の乾癬についても, 従来行われてきた治療ピラミッドのstep-upではなく, 生物学的製剤を第一選択薬として, 効果のない場合に他の治療法を検討するtop-downが主流となると予測され, 生物学的製剤は, 今後, 乾癬の治療を大きく変えると考えられる.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"67008","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuyama, Asako"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松山, 麻子"}],"nameIdentifiers":[{"nameIdentifier":"67007","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"126(6)_293-300.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"126(6)_293-300.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9688/files/126(6)_293-300.pdf"},"version_id":"abcb1c84-e29c-48e1-84bc-50d983a39456"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乾癬","subitem_subject_scheme":"Other"},{"subitem_subject":"生物学的製剤","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-_α","subitem_subject_scheme":"Other"},{"subitem_subject":"インフリキシマブ","subitem_subject_scheme":"Other"},{"subitem_subject":"アダリムマブ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"3 乾癬に対する生物学的製剤の使用経験(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"3 乾癬に対する生物学的製剤の使用経験(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)"},{"subitem_title":"3 乾癬に対する生物学的製剤の使用経験(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","942"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-09"},"publish_date":"2015-01-09","publish_status":"0","recid":"9688","relation_version_is_last":true,"title":["3 乾癬に対する生物学的製剤の使用経験(II.一般講演,各科における生物学的製剤の治療経験,第663回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:41.278471+00:00"}