{"created":"2021-03-01T06:13:22.998629+00:00","id":9316,"links":{},"metadata":{"_buckets":{"deposit":"282d73fe-943a-46b9-8417-29e49c176270"},"_deposit":{"id":"9316","owners":[],"pid":{"revision_id":0,"type":"depid","value":"9316"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00009316","sets":["453:456","471:537:538:931"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Histopathologic Features of Epileptogenic Brain Lesions"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"227","bibliographicPageStart":"221","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"難治性てんかん患者に対する外科手術が広く行われるようになり, その摘出脳組織に対する病理学的理解が進んできた. そこには, 発生異常, 神経細胞脱落, 腫瘍性病変, 血管異常, 炎症性病変, 組織破壊性病変など, 多彩なetiologyを示唆する所見が認められる. 小児期あるいはそれ以前に発症する症例では, その病態形成に脳の発生異常が深く関与している場合も多い. その代表的病態のひとつである限局性皮質異形成(FCD:focal cortical dysplasia)では, 皮質神経細胞の配列がさまざまな程度に乱れている. 高度の乱れを示す場合には, dysmorphic neuronやballoon cellと呼ばれる異型細胞を伴っている. こうした症例はFCD Type IIと分類されている. 一方, 異型細胞を伴わない場合はFCD Type Iと分類されている. この場合には, 通常, 神経細胞の配列の乱れは軽い． 結節性硬化症の皮質結節や片側巨脳症でも, FCD Type IIの異型細胞に類似した細胞が出現する. てんかん原性病巣の病態理解に向け, 神経生理学や発生学, 更には分子生物学的手法を取り入れた統合的解析が行われている. 神経病理学が果たす役割も大きい.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"64736","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kakita, Akiyoshi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柿田, 明美"}],"nameIdentifiers":[{"nameIdentifier":"64735","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"127(5)_221-227.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"127(5)_221-227.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/9316/files/127(5)_221-227.pdf"},"version_id":"43154018-2bca-446f-a329-138eb0a3cda2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"皮質異形成","subitem_subject_scheme":"Other"},{"subitem_subject":"発生異常","subitem_subject_scheme":"Other"},{"subitem_subject":"てんかん","subitem_subject_scheme":"Other"},{"subitem_subject":"神経細胞移動","subitem_subject_scheme":"Other"},{"subitem_subject":"病理","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"てんかん外科病理学の実際","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"てんかん外科病理学の実際"},{"subitem_title":"てんかん外科病理学の実際","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","931"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-22"},"publish_date":"2015-12-22","publish_status":"0","recid":"9316","relation_version_is_last":true,"title":["てんかん外科病理学の実際"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:26.099371+00:00"}