@article{oai:niigata-u.repo.nii.ac.jp:00009262,
 author = {奥田, 一博 and 吉江, 弘正 and 川瀬, 知之 and 中田, 光},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {To regenerate periodontal tissue destroyed by chronic periodontitis, autologous cultured periosteal sheets in combination with platelet-rich plasma (PRP) and hydroxyapatite (HA) granules were used as a clinical application. The periosteum specimens were dissected from each patient, and were incubated for approximately six weeks until the sheets were formed. Prior to placement of the cultured periosteal sheets, osseous defects were thoroughly debrided and filled with HA granules in combination with PRP. Standardized clinical and radiographic measurements were determined during follow-up examinations at one, two and three years. Clinical attachment level (CAL) and radiographic infrabony defect depth (IBD) were determined as primary end-point. As secondary end-point, inflammatory indices including plaque index (PI), gingival index (GI) and bleeding on probing (BOP) were determined. Results were averaged for the clinical and radiographic parameters. Taking into account the paired nature of the changes from baseline to one year, and three years in each group, the Wilcoxon signed-rank test was performed. The Mann-Whitney U test was applied to compare clinical and radiographic outcomes between test and control groups at baseline and 1 year post surgery. The null hypothesis was rejected when the risk percentage was < 5% (p<0.05). One year results of this treatment have shown favorable clinical results, and these effects were stable and maintained after three years, when compared to baseline. The cultured periosteal sheets function as a living drug delivery system to favorably influence cellular functions and serves as seeds for ectopic bone formation near the implantation site through production of important growth factors related to periodontal regeneration.},
 pages = {349--354},
 title = {3 自己培養骨膜シートを用いた歯槽骨再生研究 : データをどのように収集してどのように評価するか(シンポジウム 新潟大学の臨床研究を活性化するためにはどのような仕組みが必要か?, 第672回新潟医学会)},
 volume = {127},
 year = {2013}
}