@article{oai:niigata-u.repo.nii.ac.jp:00009052,
 author = {内藤, 眞},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {Macrophages are important immune cells for host defence and involved in the pathogenesis of various disorders. In vertebrates, primitive macrophages first develop in yolk sac hematopoiesis and differentiate into fetal macrophages. Monocytes are differentiated from hematopoietic stem cells in the late stage of fetal hematopoietic organs and bone marrow. Macrophages serve as an effector in metabolism and host defense. Macrophage scavenger receptors are involved in host defense and atherogenesis. Macrophage growth factors are critical for macrophage differentiation and function. In macrophage colony-stimulating factor-deficient osteopetrotic mice, monocytes, tissue macrophages and osteoclasts are deficient. Granulocyte macrophage colony-stimulating factor-deficient mice develop alveolar proteinosis due to impaired surfactant catabolism by alveolar macrophages. Accumulation of glucocerebroside in macrophages in lysosomes produces Gaucher cells. Macrophages incorporate chemically modified low-density lipoprotein (LDL) and transform into foam cells. Binding oxidized LDL to liver X receptor α (LXRα) upregulates the expression of its target genes, which act as cholesterol removers from macrophages. Inflammatory signals down-regulate the expression of LXRα and enhance lipid accumulation. Thus, macrophages play a pivotal role in metabolism and host defense. Clarification of molecular mechanism of macrophage function may provide useful tools for establishing therapeutic strategy against various disorders.},
 pages = {57--66},
 title = {私の歩んだ道 : マクロファージ研究を中心に},
 volume = {128},
 year = {2014}
}