{"created":"2021-03-01T06:12:52.307369+00:00","id":8830,"links":{},"metadata":{"_buckets":{"deposit":"4dc1356f-4340-4a5f-b3e5-70c0732286a7"},"_deposit":{"id":"8830","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8830"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008830","sets":["453:456","471:537:538:539"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Liver X Receptor-α Localizes in Nucleolus and Stimulates rDNA Transcription"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"461","bibliographicPageStart":"447","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"LXRα (Liver X receptor α)はLDL (low density lipoprotein)など酸化ステロールの受容体として機能し, 脂質代謝, 胆汁酸代謝などに関与する核内受容体である. しかし特異性の高い抗体がこれまでなかったためmRNAレベルの研究が多く, その組織細胞内局在や機能については不明な点が多い. 本研究では最近作製されたLXRαに対する特異的抗体を用いて, LXRαの細胞内局在とこれまで知られていなかったリボソーム生合成への関与について解析を行ったので報告する. LXRαは核小体内においてfibrillarin, UBFおよびRNA polymerase I (RNA pol I)の転写活性の高い領域, すなわちdense fibrillar componentと呼ばれる領域に局在することがわかった. HepG2細胞においてRNA pol Iの転写活性をActinomycin D投与によって抑制すると, LXRαは核小体内に局在できず核質へ移行したことからLXRαの核小体内局在はRNA pol Iの転写活性に依存していることがわかった. クロマチン免疫沈降法を用いた検討の結果, LXRαは18S rDNAと28S rDNAに結合することが判明した. さらに, HepG2細胞に対してLXRαを活性化する合成リガンドであるT0901317を投与するとリボゾーム前駆体47S/45S rRNAの転写が促進されたが, LXRαをsiRNAでノックダウンすると転写促進が起こらなかった. 以上の結果より, LXRαはリボソーム生合成において重要な役割を担っていることが示唆された.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"61440","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohashi, Riuko"}]},{"nameIdentifiers":[{"nameIdentifier":"61441","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ajioka, Yoichi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大橋, 瑠子"}],"nameIdentifiers":[{"nameIdentifier":"61438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"味岡, 洋一"}],"nameIdentifiers":[{"nameIdentifier":"61439","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"128(9)_447-461.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"128(9)_447-461.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8830/files/128(9)_447-461.pdf"},"version_id":"aa830db8-4a63-4e8c-a0dc-64f523d2564a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"LXRα","subitem_subject_scheme":"Other"},{"subitem_subject":"核小体","subitem_subject_scheme":"Other"},{"subitem_subject":"リボソームRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrillarin","subitem_subject_scheme":"Other"},{"subitem_subject":"UBF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"LXRαの核小体への局在とリボソームDNA転写制御","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"LXRαの核小体への局在とリボソームDNA転写制御"},{"subitem_title":"LXRαの核小体への局在とリボソームDNA転写制御","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","539"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-09-16"},"publish_date":"2016-09-16","publish_status":"0","recid":"8830","relation_version_is_last":true,"title":["LXRαの核小体への局在とリボソームDNA転写制御"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:43:07.427188+00:00"}