{"_buckets": {"deposit": "7f33eb20-83ef-4cf8-934d-71284671065c"}, "_deposit": {"id": "8797", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "8797"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00008797"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Clinical Application of Cultured Human Periosteum Sheet for Periodontitis Patients"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "573", "bibliographicPageStart": "568", "bibliographicVolumeNumber": "128", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "To regenerate periodontal tissue destroyed by chronic periodontitis, autologous cultured periosteal sheets in combination with platelet-rich plasma (PRP) and hydroxyapatite (HA) granules were used as a clinical application. The periosteum specimens were dissected from each patient, and were incubated for approximately six weeks until the sheets were formed. Prior to placement of the cultured periosteal sheets, osseous defects were thoroughly debrided and filled with HA granules in combination with PRP. Standardized clinical and radiographic measurements were determined during follow-up examinations at one, two, three, four and five years. Clinical attachment level (CAL) and radiographic infrabony defect depth (IBD) were determined as primary end-point. One year results of this treatment have shown favorable clinical results, and these effects were stable and maintained after five years, when compared to baseline and three years. The cultured periosteal sheets function as a living drug delivery system to favorably influence cellular functions and serves as seeds for ectopic bone formation near the implantation site through production of important growth factors related to periodontal regeneration. Tissue engineering is a novel means which we believe will be used extensively in the future to treat periodontal osseous defects. Once a successful clinical treatment has been achieved with a combination of HCP sheets, PRP and HA granules, the results are maintainable 5 years. In addition to the favorable long term clinical results for treating periodontal osseous defects, the long-term safety of tissue engineered HCP sheets in periodontal therapy was established.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "61249", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Okuda, Kazuhiro"}]}, {"nameIdentifiers": [{"nameIdentifier": "61250", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kawase, Tomoyuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "61251", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakata, Koh"}]}, {"nameIdentifiers": [{"nameIdentifier": "61252", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yoshie, Hiromasa"}]}, {"nameIdentifiers": [{"nameIdentifier": "61253", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Saeki, Makio"}]}]}, "item_7_publisher_7": {"attribute_name": 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