{"created":"2021-03-01T06:12:30.906872+00:00","id":8495,"links":{},"metadata":{"_buckets":{"deposit":"d56d168e-7af9-4ff4-8daa-2b3178df0a50"},"_deposit":{"id":"8495","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8495"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008495","sets":["453:456","471:537:538:902"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Leading-edge　Analysis　of　RNA-binding　Protein"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"84","bibliographicPageStart":"79","bibliographicVolumeNumber":"130","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RNA結合蛋白質は, 非コード, コードRNAを含む, RNAのプロセシング, 局在化, 安定性, 翻訳といった転写後調節機構を担う分子群である. ここ2-3年の間に, RNA結合蛋白質は, ヒトゲノムにおいて蛋白質がコードされる遺伝子の約7.5%にあたる約1,542種類存在もする事が分かってきた. 実は, そのおよそ半数以上がつい最近明らかとなったという驚きと同時に, この発見はRNA結合蛋白質への注目度の高さを意味しているとも言える. そこで, RNA結合蛋白質研究の意義及び, その解析戦略について最新のトピックスを踏まえて概説したい. 「RNA結合蛋白質研究の意義を探る」 転写後調節システムは, ほぼ全ての生命現象に必須な情報制御機構であり, それぞれのRNAが保持する配列暗号を多くのRNA結合蛋白質群が認識することで調整が行われていると考えられている. まず, この転写後調節機構を担うRNA結合蛋白質研究の意義を深める上での重要な発見, および医療応用について述べたい.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"59166","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yano, Masato"}]},{"nameIdentifiers":[{"nameIdentifier":"59167","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takebayashi, Hirohide"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢野, 真人"}],"nameIdentifiers":[{"nameIdentifier":"59164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹林, 浩秀"}],"nameIdentifiers":[{"nameIdentifier":"59165","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"130(2)_79-84.pdf","filesize":[{"value":"501.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"130(2)_79-84.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8495/files/130(2)_79-84.pdf"},"version_id":"1db1de60-68c1-44ba-9178-cb559aa536a8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RNA結合蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"転写後調節","subitem_subject_scheme":"Other"},{"subitem_subject":"神経発生学","subitem_subject_scheme":"Other"},{"subitem_subject":"HITS-CLIP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"RNA結合蛋白質の機能解析最前線","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNA結合蛋白質の機能解析最前線"},{"subitem_title":"RNA結合蛋白質の機能解析最前線","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","902"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-17"},"publish_date":"2016-10-17","publish_status":"0","recid":"8495","relation_version_is_last":true,"title":["RNA結合蛋白質の機能解析最前線"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:51.775108+00:00"}