{"created":"2021-03-01T06:12:26.998962+00:00","id":8433,"links":{},"metadata":{"_buckets":{"deposit":"289892a0-12f0-45c2-83a7-478cc25f0097"},"_deposit":{"id":"8433","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8433"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008433","sets":["453:456","471:537:538:897"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Familial Lung Cancer"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"384","bibliographicPageStart":"381","bibliographicVolumeNumber":"130","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上皮成長因子受容体(EGFR)遺伝子変異陽性肺がんは, ｢腺がん，アジア糸人種,女性，非喫煙者」に多く，その発がん機構には遺伝学的背景が示唆されている. 最近われわれは, 7人兄弟のうち， 4人にEGFR遺伝子変異陽性肺がんが集積している家族例を経験し，その遺伝学的背景の存在を再認識させられた．そこで，その詳細を明らかにする目的で，家族例患者の末梢血DNAを用いたエクソーム解析を行った、本稿では，その解析結果を一部紹介し，全ゲノム関連解析と対比させながら，疾患の原因遺伝子を探索する研究手法について考案する．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"58847","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kikuchi, Toshiaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菊地, 利明"}],"nameIdentifiers":[{"nameIdentifier":"58846","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"130(7)_381-384.pdf","filesize":[{"value":"240.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"130(7)_381-384.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8433/files/130(7)_381-384.pdf"},"version_id":"78861f41-967e-405b-82e1-630b8e408ecb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"家族性肺がん","subitem_subject_scheme":"Other"},{"subitem_subject":"EGFR遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"エクソーム解析","subitem_subject_scheme":"Other"},{"subitem_subject":"全ゲノム関連解析","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"家族性肺がんのエクソーム解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"家族性肺がんのエクソーム解析"},{"subitem_title":"家族性肺がんのエクソーム解析","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","897"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-11-11"},"publish_date":"2016-11-11","publish_status":"0","recid":"8433","relation_version_is_last":true,"title":["家族性肺がんのエクソーム解析"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:45.736996+00:00"}