{"created":"2021-03-01T06:12:19.513892+00:00","id":8314,"links":{},"metadata":{"_buckets":{"deposit":"54e4b767-aaed-4722-af00-958606d897c7"},"_deposit":{"id":"8314","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8314"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008314","sets":["453:456","471:537:538:889"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Therapeutic Approaches for HCV infection : Tactics for difficult - to - treat populations"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"146","bibliographicPageStart":"143","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DAAを用いた治療により, HCV感染症の治療適応が大きく広がった. Daclatasvir+Asunaprevir治療は, 宿主要因に影響されず高い治療効果が達成できるが, 薬剤耐性変異ウイルスの影響を大きく受ける. ポリメラーゼ阻害薬Sofosbuvirは, 複数のHCVゲノタイプに対して効果を示す. Genotype 2型に対して, Ribavirinとの併用で, 96.7%のSVRが得られる. Genotype 1型に対してはSofosbuvirとLedipasvir複合錠の12週投与で100%の著効率を達成している. HCV排除後も肝発癌リスクのコントロール, 残存する肝硬変に対する治療など課題が多く, 今後急速に変わるHCV治療の動向を把握しつつ認識を一新する必要がある.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"58297","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakamoto, Naoya"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 直哉"}],"nameIdentifiers":[{"nameIdentifier":"58296","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(3)_143-146.pdf","filesize":[{"value":"441.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"131(3)_143-146.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8314/files/131(3)_143-146.pdf"},"version_id":"0254a0d8-bf94-4bf5-a240-511ba5056b22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Direct-acting antivirals","subitem_subject_scheme":"Other"},{"subitem_subject":"Protease inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"NS5A inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymerase inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon-free protocol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2 C型肝炎治療 : 難治例の対策とさらなる課題 (シンポジウム 肝炎治療に関する最近の進歩, 第716回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2 C型肝炎治療 : 難治例の対策とさらなる課題 (シンポジウム 肝炎治療に関する最近の進歩, 第716回新潟医学会)"},{"subitem_title":"2 C型肝炎治療 : 難治例の対策とさらなる課題 (シンポジウム 肝炎治療に関する最近の進歩, 第716回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","889"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-09-22"},"publish_date":"2017-09-22","publish_status":"0","recid":"8314","relation_version_is_last":true,"title":["2 C型肝炎治療 : 難治例の対策とさらなる課題 (シンポジウム 肝炎治療に関する最近の進歩, 第716回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:40.754485+00:00"}