{"created":"2021-03-01T06:12:16.361654+00:00","id":8264,"links":{},"metadata":{"_buckets":{"deposit":"eaf7e258-f512-4f2f-a19c-37fe0657f4b6"},"_deposit":{"id":"8264","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8264"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008264"},"item_7_alternative_title_1":{"attribute_name":"\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb","attribute_value_mlt":[{"subitem_alternative_title":"Pathological Differences between Ulcerative Colitis-associated Dysplasia and Sporadic Adenoma"}]},"item_7_biblio_info_6":{"attribute_name":"\u66f8\u8a8c\u60c5\u5831","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"362","bibliographicPageStart":"350","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"},{"bibliographic_title":"\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"\u6284\u9332","attribute_value_mlt":[{"subitem_description":"\u3010\u80cc\u666f\u3011\u9577\u671f\u7d4c\u904e\u306e\u6f70\u760d\u6027\u5927\u8178\u708e (ulcerative colitis: \u4ee5\u4e0bUC) \u306e\u5408\u4f75\u75c7\u3068\u3057\u3066\u5927\u8178\u764c\u306e\u767a\u751f\u304c\u3042\u308b. UC\u306b\u767a\u751f\u3059\u308b\u5927\u8178\u764c\u306fdysplasia\u3068\u547c\u3070\u308c\u308b\u7c98\u819c\u5185\u816b\u760d\u3092\u524d\u764c\u75c5\u5909\u3068\u3059\u308b\u3053\u3068, \u304a\u3088\u3073dysplasia\u306b\u306f\u540c\u6642\u6027\u7570\u6642\u6027\u306e\u764c\u767a\u751f\u3092\u4e88\u6e2c\u3059\u308b\u30ea\u30b9\u30af\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u610f\u7fa9\u3082\u3042\u308b\u3053\u3068\u304b\u3089, \u5185\u8996\u93e1\u7684\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u306e\u751f\u691c\u3067dysplasia\u306e\u75c5\u7406\u8a3a\u65ad\u304c\u306a\u3055\u308c\u305f\u5834\u5408\u306f, \u5927\u8178\u5168\u6458\u304c\u6cbb\u7642\u7b2c\u4e00\u9078\u629e\u3068\u3057\u3066\u63a8\u5968\u3055\u308c\u3066\u304d\u305f. \u4ed6\u65b9, UC\u5927\u8178\u7c98\u819c\u306b\u306fdysplasia\u4ee5\u5916\u306b, \u901a\u5e38\u306e\u817a\u816b\u3082\u5076\u767a\u3059\u308b\u3053\u3068\u304c\u3042\u308b (\u6563\u767a\u6027\u817a\u816b) . \u3053\u308c\u3089\u306b\u5bfe\u3057\u3066\u306f, \u7d4c\u904e\u89b3\u5bdf\u3082\u3057\u304f\u306f\u5185\u8996\u93e1\u7684\u5207\u9664\u304c\u6cbb\u7642\u7b2c\u4e00\u9078\u629e\u3067\u3042\u308b. \u3057\u304b\u3057, \u6cbb\u7642\u65b9\u91dd\u304c\u5168\u304f\u7570\u306a\u308b\u4e21\u8005\u306e\u751f\u691c\u7d44\u7e54\u306b\u3088\u308b\u9451\u5225\u306f\u56f0\u96e3\u306a\u3053\u3068\u3082\u5c11\u306a\u304f\u306a\u3044. \u672c\u7814\u7a76\u306f, UC\u306edysplasia\u3068\u6563\u767a\u6027\u817a\u816b\u306e\u75c5\u7406\u5b66\u7684\u9451\u5225\u6cd5\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066, \u7d30\u80de\u5897\u6b96\u52d5\u614b, p53\u86cb\u767d\u904e\u5270\u767a\u73fe, \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9, \u03b1-methylacyl-CoA racemase (AMACR) \u767a\u73fe\u306edysplasia\u3068\u901a\u5e38\u306e\u817a\u816b\u306b\u304a\u3051\u308b\u767a\u73fe\u69d8\u5f0f\u3092\u691c\u8a0e\u3057\u305f. \u3010\u5bfe\u8c61\u3068\u65b9\u6cd5\u3011UC\u306b\u8a8d\u3081\u3089\u308c\u305fdysplasia29\u75c5\u5909\u3068, \u708e\u75c7\u6027\u8178\u75be\u60a3\u3092\u5408\u4f75\u3057\u306a\u3044\u901a\u5e38\u306e\u5927\u8178\u306b\u767a\u751f\u3057\u305f\u817a\u816b40\u75c5\u5909\u3092\u5bfe\u8c61\u3068\u3057\u3066, Ki-67\u514d\u75ab\u67d3\u8272, p53\u514d\u75ab\u67d3\u8272, AMACR\u514d\u75ab\u67d3\u8272, M30 cytoDeath\u514d\u75ab\u67d3\u8272\u3092\u884c\u3044, \u5897\u6b96\u5e2f\u306e\u5206\u5e03\u69d8\u5f0f, p53\u86cb\u767d\u904e\u5270\u767a\u73fe\u306e\u6709\u7121, AMACR\u306e\u767a\u73fe\u983b\u5ea6\u3068\u967d\u6027\u7d30\u80de\u306e\u5206\u5e03\u69d8\u5f0f, \u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u983b\u5ea6, \u3092\u691c\u8a0e\u3057\u305f. \u3010\u7d50\u679c\u3011Ki-67\u67d3\u8272\u3067\u306f, dysplasia\u7fa4\u3068\u817a\u816b\u7fa4\u3067\u4e2d\u592e\u5024\u306b\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f\u304c, \u4e21\u8005\u3067\u5897\u6b96\u5e2f\u306e\u5206\u5e03\u306f\u6709\u610f\u306b\u7570\u306a\u3063\u3066\u304a\u308a (P<0.001) , dysplasia\u7fa4\u3067\u306fbasal\u306e\u983b\u5ea6\u304c\u6700\u3082\u9ad8\u304f (55.2%) , \u817a\u816b\u7fa4\u3067\u306fsuperficial\u306e\u983b\u5ea6\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f (65.0%) . p53\u86cb\u767d\u904e\u5270\u767a\u73fe\u306e\u983b\u5ea6\u306f, dysplasia\u7fa4\u304c\u817a\u816b\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f (51.7% vs. 15.0%, P<0.0001) . AMACR\u767a\u73fe\u983b\u5ea6\u306fdysplasia\u7fa4\u3068\u817a\u816b\u7fa4\u3068\u3067\u6709\u610f\u5dee\u306f\u306a\u304b\u3063\u305f (82.8% vs. 82.5%) \u304c, \u767a\u73fe\u7d30\u80de\u306e\u5206\u5e03\u69d8\u5f0f\u306f, dysplasia\u7fa4\u306e72.5%\u304cbasal\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057, \u817a\u816b\u7fa4\u3067\u306f70.0%\u304cdiffuse\u3067\u3042\u3063\u305f. AI (apototic index) \u306f, dysplasia\u7fa4\u304c\u817a\u816b\u7fa4\u304c\u6bd4\u3079\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f (1.76% vs. 0.61%) . AI\u306e\u30ab\u30c3\u30c8\u30aa\u30d5\u5024\u30922.0\u306b\u8a2d\u5b9a\u3059\u308b\u3068, dysplasia\u7fa4\u306f2.0\u4ee5\u4e0a\u3068\u672a\u6e80\u304c\u307b\u307c\u534a\u6570\u3067\u3042\u3063\u305f\u304c, \u817a\u816b\u7fa4\u3067\u306f1\u75c5\u5909\u3092\u9664\u304d\u5168\u4f8b\u304c2.0\u672a\u6e80\u3067\u3042\u3063\u305f, \u691c\u8a0e\u3057\u305f4\u56e0\u5b50\u3092\u3082\u3068\u306b\u5bfe\u8c61\u75c5\u5909\u3092\u5c64\u5225\u5316\u3057, dysplasia\u3068\u6563\u767a\u6027\u817a\u816b\u9451\u5225\u306e\u305f\u3081\u306e\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u4f5c\u6210\u3057\u305f. \u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u306b\u3088\u308a\u672c\u7814\u7a76\u3067\u5bfe\u8c61\u3068\u3057\u305fdysplasia\u306e75.9%\u3068\u817a\u816b\u306e87.5%\u306f\u6392\u4ed6\u7684\u8a3a\u65ad\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f. \u3010\u7d50\u8ad6\u3011UC\u306edysplasia\u3068\u6563\u767a\u6027\u817a\u816b\u306e\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u9451\u5225\u306b\u306f, \u5f93\u6765\u3088\u308a\u305d\u306e\u6709\u7528\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5897\u6b96\u5e2f\u306e\u5206\u5e03\u69d8\u5f0f, p53\u86cb\u767d\u904e\u5270\u767a\u73fe\u306b\u52a0\u3048, AMACR\u767a\u73fe\u69d8\u5f0f\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u983b\u5ea6\u3082\u6709\u7528\u306a\u56e0\u5b50\u3068\u8003\u3048\u3089\u308c\u305f. \u3053\u308c\u30894\u3064\u306e\u56e0\u5b50\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7cfb\u7d71\u7684\u75c5\u7406\u8a3a\u65ad\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u308a, dysplasia\u3068\u6563\u767a\u6027\u817a\u816b\u306e\u3088\u308a\u7cbe\u5ea6\u306e\u9ad8\u3044\u9451\u5225\u304c\u53ef\u80fd\u306b\u306a\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u308b. \u4eca\u5f8c, UC\u7c98\u819c\u306b\u767a\u751f\u3057\u305f\u7a2e\u3005\u306e\u7570\u578b\u4e0a\u76ae\u306b\u672c\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3092\u9069\u7528\u3057\u305f\u524d\u5411\u304d\u7814\u7a76\u3092\u884c\u3046\u3053\u3068\u3067, \u305d\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u308b.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"\u8457\u8005\u5225\u540d","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57958","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nagashima, 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\u85cd\u5b50"}],"nameIdentifiers":[{"nameIdentifier":"57957","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"\u30d5\u30a1\u30a4\u30eb\u60c5\u5831","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(6)_350-362.pdf","filesize":[{"value":"9.2 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\u3068\u6563\u767a\u6027\u817a\u816b\u3068\u306e\u75c5\u7406\u5b66\u7684\u9451\u5225","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["453/456","471/537/538/886"],"pubdate":{"attribute_name":"\u516c\u958b\u65e5","attribute_value":"2018-01-05"},"publish_date":"2018-01-05","publish_status":"0","recid":"8264","relation_version_is_last":true,"title":["\u6f70\u760d\u6027\u5927\u8178\u708e\u306e\u708e\u75c7\u6027\u767a\u764c\u65e9\u671f\u75c5\u5909 (dysplasia) \u3068\u6563\u767a\u6027\u817a\u816b\u3068\u306e\u75c5\u7406\u5b66\u7684\u9451\u5225"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2021-03-01T18:48:53.475686+00:00"}