{"created":"2021-03-01T06:12:13.922112+00:00","id":8226,"links":{},"metadata":{"_buckets":{"deposit":"a526d9bc-0262-4684-b08c-855d3796f5b9"},"_deposit":{"id":"8226","owners":[],"pid":{"revision_id":0,"type":"depid","value":"8226"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00008226","sets":["453:456","471:537:538:884"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Eculizumab Treatment of Atypical Hemolytic Uremic Syndrome"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"475","bibliographicPageStart":"472","bibliographicVolumeNumber":"131","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"非典型溶血性尿毒症症候群(atypical hemolytic uremic syndrome: aHUS)は，補体の異常活性化により発症する血栓性微小血管症(thrombotic microangiopathy: TMA)である．近年aHUSの病態解明が進み，その病因として次々と補体制御因子の遺伝子異常が発見されている．予後不良の難治性疾患として知られていたが，治療薬として補体C5に対するモノクローナル抗体(エクリズマブ)が承認され，治療法が大きく進歩した．本稿では，当科で経験したaHUS症例を提示し，aHUSの病態・治療につき概説する．","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"57749","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamada, Takeshi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 剛史"}],"nameIdentifiers":[{"nameIdentifier":"57748","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"131(8)_472-475.pdf","filesize":[{"value":"828.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"131(8)_472-475.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/8226/files/131(8)_472-475.pdf"},"version_id":"fe73323b-edde-4ab6-837d-49cf4826463d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エクリズマブ","subitem_subject_scheme":"Other"},{"subitem_subject":"非典型溶血性尿毒症症候群","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"7 小児科領域 エクリズマブによるaHUS治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"7 小児科領域 エクリズマブによるaHUS治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）"},{"subitem_title":"7 小児科領域 エクリズマブによるaHUS治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","884"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-28"},"publish_date":"2018-02-28","publish_status":"0","recid":"8226","relation_version_is_last":true,"title":["7 小児科領域 エクリズマブによるaHUS治療 （シンポジウム 各科領域における生物学的製剤の現況と展望, 第720回新潟医学会）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:42:36.192667+00:00"}